Document Detail


Concentration of purine compounds in the cerebrospinal fluid of infants suffering from sepsis, convulsions and hydrocephalus.
MedLine Citation:
PMID:  8568608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Catabolites of purine nucleotides were measured in the cerebrospinal fluid (CSF) of newborn infants with sepsis, seizures and hydrocephalus using isocratic reversed-phase HPLC. The inosine levels in the CSF of the infants with any of the illnesses were significantly higher when compared with the controls. There was a tendency for hypoxanthine levels to be higher in the group of children with hydrocephalus. No significant differences in the concentrations of xanthine, adenine and uric acid were found. The inosine concentration in the CSF is proposed to be a more sensitive indicator of brain injury than the levels of other CSF purines. The levels of all purine metabolites measured in the CSF showed large individual variations. The ratio between hypoxanthine (as an indicator of ATP breakdown) and uric acid (as a scavenger of oxygen free radicals) concentration is proposed as a new criterion to be used in the evaluation of brain injury.
Authors:
H Schmidt; W G Siems; T Grune; E L Grauel
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  23     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  1995  
Date Detail:
Created Date:  1996-03-07     Completed Date:  1996-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  167-74     Citation Subset:  IM    
Affiliation:
Children's Hospital Singen, Fed. Rep. of Germany.
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MeSH Terms
Descriptor/Qualifier:
Adenine / cerebrospinal fluid
Bacterial Infections / cerebrospinal fluid*,  diagnosis
Chromatography, High Pressure Liquid
Humans
Hydrocephalus / cerebrospinal fluid*,  diagnosis
Hypoxanthine
Hypoxanthines / cerebrospinal fluid
Infant
Infant, Newborn
Inosine / cerebrospinal fluid
Predictive Value of Tests
Purines / cerebrospinal fluid*
Seizures / cerebrospinal fluid*,  diagnosis
Uric Acid / cerebrospinal fluid
Xanthine
Xanthines / cerebrospinal fluid
Chemical
Reg. No./Substance:
0/Hypoxanthines; 0/Purines; 0/Xanthines; 58-63-9/Inosine; 68-94-0/Hypoxanthine; 69-89-6/Xanthine; 69-93-2/Uric Acid; 73-24-5/Adenine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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