Document Detail


Concentration and molecular forms of active and inactive renin in human fetal kidney, amniotic fluid and adrenal gland: evidence for renin-angiotensin system hyperactivity in 2nd trimester of pregnancy.
MedLine Citation:
PMID:  3007602     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a study of 38 fetuses total kidney renin was significantly correlated with gestational age (r = 0.63). Although whole fetal kidney renin specific activity was found to decrease with gestational age (r = -0.65), the mean value of the specific activity was about 20 times greater than in normal adult cortex and double that in tissue from patients with renal artery stenosis, suggesting renin-angiotensin system hyperactivity. In approximately 40% of fetal kidneys examined, evidence for an inactive (trypsin-activatable) renin precursor was found. The molecular weight of this form was indistinguishable from active renin (45 000 daltons) by Sephadex chromatography. Amniotic fluid from nine cases (100%) contained angiotensin (ANG) 1, angiotensin converting enzyme (ACE), renin substrate, active and inactive renin (both 45 000 daltons). Five of the 38 (13%) fetal adrenal glands contained renin, but no evidence for trypsin-activatable forms. Aldosterone was present in low concentration in the earliest adrenals examined, and a positive correlation existed between total tissue aldosterone and gestational age (r = 0.73). These findings suggest that the fetal renin-angiotensin system has an important role to play in the maintenance of extracellular fluid volume and blood pressure in the developing fetus.
Authors:
G M Taylor; W S Peart; K A Porter; L H Zondek; T Zondek
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  4     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-05-07     Completed Date:  1986-05-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  121-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / metabolism
Aldosterone / metabolism
Amniotic Fluid / metabolism
Angiotensin I / metabolism
Enzyme Activation / drug effects
Female
Fetus / metabolism*,  ultrastructure
Gestational Age
Humans
Kidney / metabolism,  ultrastructure
Male
Peptidyl-Dipeptidase A / metabolism
Pregnancy
Renin / metabolism*
Renin-Angiotensin System*
Trypsin / pharmacology
Chemical
Reg. No./Substance:
52-39-1/Aldosterone; 9041-90-1/Angiotensin I; EC 3.4.15.1/Peptidyl-Dipeptidase A; EC 3.4.21.4/Trypsin; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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