| Concentration and molecular forms of active and inactive renin in human fetal kidney, amniotic fluid and adrenal gland: evidence for renin-angiotensin system hyperactivity in 2nd trimester of pregnancy. | |
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MedLine Citation:
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PMID: 3007602 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a study of 38 fetuses total kidney renin was significantly correlated with gestational age (r = 0.63). Although whole fetal kidney renin specific activity was found to decrease with gestational age (r = -0.65), the mean value of the specific activity was about 20 times greater than in normal adult cortex and double that in tissue from patients with renal artery stenosis, suggesting renin-angiotensin system hyperactivity. In approximately 40% of fetal kidneys examined, evidence for an inactive (trypsin-activatable) renin precursor was found. The molecular weight of this form was indistinguishable from active renin (45 000 daltons) by Sephadex chromatography. Amniotic fluid from nine cases (100%) contained angiotensin (ANG) 1, angiotensin converting enzyme (ACE), renin substrate, active and inactive renin (both 45 000 daltons). Five of the 38 (13%) fetal adrenal glands contained renin, but no evidence for trypsin-activatable forms. Aldosterone was present in low concentration in the earliest adrenals examined, and a positive correlation existed between total tissue aldosterone and gestational age (r = 0.73). These findings suggest that the fetal renin-angiotensin system has an important role to play in the maintenance of extracellular fluid volume and blood pressure in the developing fetus. |
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Authors:
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G M Taylor; W S Peart; K A Porter; L H Zondek; T Zondek |
Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Journal of hypertension Volume: 4 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 1986 Feb |
Date Detail:
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Created Date: 1986-05-07 Completed Date: 1986-05-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 121-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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metabolism Aldosterone / metabolism Amniotic Fluid / metabolism Angiotensin I / metabolism Enzyme Activation / drug effects Female Fetus / metabolism*, ultrastructure Gestational Age Humans Kidney / metabolism, ultrastructure Male Peptidyl-Dipeptidase A / metabolism Pregnancy Renin / metabolism* Renin-Angiotensin System* Trypsin / pharmacology |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone; 9041-90-1/Angiotensin I; EC 3.4.15.1/Peptidyl-Dipeptidase A; EC 3.4.21.4/Trypsin; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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