Document Detail


Concentration of malondialdehyde (MDA) in amniotic fluid and maternal and cord serum in cases of intrauterine growth retardation.
MedLine Citation:
PMID:  8048286     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of our investigation was an attempt to determine malondialdehyde concentration (MDA) in amniotic fluid as a biochemical test in prenatal diagnosis. The investigations were carried out in 56 pregnant women and their newborns in whom IUGR was diagnosed clinically. The control group consisted of 35 pregnants who had as uneventful pregnancy and normal labour. Samples of amniotic fluid were taken in the first stage of parturition (dilatation of cervical os 4-5 cm) by vaginal amniocentesis or amniotomy during cesarean section. It was found that during pregnancy complicated by IUGR, the MDA concentration in amniotic fluid was almost three times higher than in normal pregnancy (0.785 mmol/l and 0.268 mmol/l, respectively). These differences are statistically significant at p < 0.001. Thus, determination of MDA can be used as a biochemical test in parental diagnosis of IUGR.
Authors:
G Bazowska; A Jendryczko
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zentralblatt für Gynäkologie     Volume:  116     ISSN:  0044-4197     ISO Abbreviation:  Zentralbl Gynakol     Publication Date:  1994  
Date Detail:
Created Date:  1994-08-31     Completed Date:  1994-08-31     Revised Date:  2008-02-11    
Medline Journal Info:
Nlm Unique ID:  21820100R     Medline TA:  Zentralbl Gynakol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  329-30     Citation Subset:  IM    
Affiliation:
Department of Gynecology and Obstetrics, Silesian Medical School, Zabrze.
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MeSH Terms
Descriptor/Qualifier:
Amniotic Fluid / metabolism*
Female
Fetal Blood / metabolism*
Fetal Growth Retardation / blood,  diagnosis*
Gestational Age
Humans
Infant, Newborn
Malondialdehyde / blood*
Maternal-Fetal Exchange / physiology*
Obstetric Labor, Premature / blood,  diagnosis
Pregnancy
Prenatal Diagnosis*
Reference Values
Chemical
Reg. No./Substance:
542-78-9/Malondialdehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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