Document Detail

Concentration in blood and organs of dogs after high dose 1,1,1-trichloroethane inhalation.
MedLine Citation:
PMID:  9348717     Owner:  NLM     Status:  MEDLINE    
Dogs were exposed to 1% (v/v) (10,000 ppm) vapor of 1,1,1-Trichloroethane (1,1,1-TCE) by inhalation for 3 min repeated four times at 4 hr intervals under continuous anesthesia. Changes in the 1,1,1-TCE concentration in blood with time, as well as distribution of 1,1,1-TCE in the organs and tissues (lungs, liver, kidneys, heart, brain, and fat around the kidneys and on the abdominal wall) upon completion of the four exposures were studied. Concentrations of 1,1,1-TCE in blood showed the highest level immediately after exposure, and fairly decreased in about 30 min after exposure. The half life of 1,1,1-TCE in blood was 4-12 min after exposure. Upon completion of the exposures (3 min inhalations repeated four times), 1,1,1-TCE concentrations per gram wet weight of each organ ranged from 0.1 to 0.5 microgram/g in the lungs, liver, kidneys, heart and brain. On the other hand, the 1,1,1-TCE concentration in fat ranged from 16.9 to 54.6 micrograms/g, greatly exceeding those in other organs.
H Katagiri; N Aoki; K Soma; H Karube; Y Aizawa; T Kadowaki; Y Inoue
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Industrial health     Volume:  35     ISSN:  0019-8366     ISO Abbreviation:  Ind Health     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-11-25     Completed Date:  1997-11-25     Revised Date:  2013-01-24    
Medline Journal Info:
Nlm Unique ID:  2985065R     Medline TA:  Ind Health     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  461-6     Citation Subset:  IM    
Department of Public Health, Kitasato University School of Allied Health Sciences, Sagamihara, Japan.
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MeSH Terms
Adipose Tissue / drug effects,  metabolism
Inhalation Exposure / adverse effects*
Solvents / metabolism*
Time Factors
Trichloroethanes / blood,  metabolism*
Reg. No./Substance:
0/Solvents; 0/Trichloroethanes; 113C650IR1/1,1,1-trichloroethane

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