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Concentration of free vascular endothelial growth factor and its soluble receptor, sFlt-1 in the maternal and fetal circulations of normal term pregnancies at high and low altitudes.
MedLine Citation:
PMID:  22385323     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: Vascular Endothelial Growth Factor (VEGF) is regulated by hypoxia that is essential for placental development. It is antagonized by a soluble form of its receptor (sFlt-1). The purpose of this study was to measure these factors in the maternal and the cord bloods, at low and high altitude. Methods: Samples were collected from full term births normal pregnant women. Free (unbound) VEGF and sFlt-1 levels were measured in plasma samples from cord and maternal blood for each subject by Enzyme Linked Immunosorbent Assay (ELISA) using commercially available kits from R&D systems, UK (Cat # DVE00 and Cat # SVR100B respectively). Results: At high altitude, the average maternal free VEGF in pg/ml was significantly (P < 0.001) lower than that of the cord level (71.30 +282.14 and 431.35 +424.31 respectively). On the other hand, the average maternal sFlt-1 was significantly (P < 0.001) higher than that of the cord level (8205.41 +6244.72 and 1811.74 +3469.30 respectively). At low altitude, the average maternal free VEGF was significantly lower than that of the cord level (0.47 +0.89 and 483.44 +457.31 respectively, P < 0.001). On the other hand, the average maternal sFlt-1 was significantly higher than that of the cord level (9267.82 +6345.68 and 958.66 +1359.92 respectively, P<0.001). There were no significant differences by altitude. Conclusion: Secretion of sFlt-1 appears to be polarized, in that concentrations are higher in the maternal compartment than on the fetal side at both high and low altitudes. This may be a normal physiological phenomenon to permit angiogenesis in the placenta and fetus while protecting the mother. Chronic exposure to hypobaric hypoxia at high altitude does not affect these distributions.
Authors:
Kamal Z M Ali; Graham J Burton; Ali M Al-Binali; Mamdoh A Eskandar; Awad A El-Mekki; Riyad A Moosa; Salah A Abd-Alla; Ali G A Salih; Abulqasim M B Sideeg; Ahmed A Mahfouz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-2
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Anatomy, College of Medicine, King Khalid University, Abha, Saudi Arabia.
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