| Concentration-effect relationships and implications for trough-to-peak ratio. | |
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MedLine Citation:
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PMID: 8896666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The guidelines on trough-to-peak ratio identified an index of the duration of action of an antihypertensive drug (relative to its dosage interval) to prevent the use of inappropriately large doses of drug simply to extend the apparent duration of action. In some instances, however, trough-to-peak ratio may be dose-dependent and this analysis examines the contribution that the underlying concentration-antihypertensive effect relationship makes to the dose dependency of trough-to-peak ratio. Where this concentration-effect relationship is essentially linear the trough-to-peak ratio is almost invariably dose-independent. In contrast, where the relationship is identified as being of a sigmoid-Emax type the trough-to-peak ratio is likely to be dose-dependent. The nature of the concentration-effect relationship also influences the duration of action beyond the dosage interval whereby "linear" drugs are superior to "Emax" drugs by virtue of the greater persistence of the antihypertensive effect. |
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Authors:
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P A Meredith; H L Elliott |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American journal of hypertension Volume: 9 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 1996 Oct |
Date Detail:
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Created Date: 1997-02-11 Completed Date: 1997-02-11 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 66S-70S; discussion 87S-90S Citation Subset: IM |
Affiliation:
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University Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, Scotland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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pharmacology*,
therapeutic use Dose-Response Relationship, Drug* Humans Hypertension / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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