Document Detail


Concentration-dependent increase of murine P388 and B16 population doubling time by the acyclic monoterpene geraniol.
MedLine Citation:
PMID:  1988098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Geraniol, an acyclic end product of a plant isoprene pathway and a pyrophosphorylated intermediate in plant and animal pathways, caused a concentration-dependent increase in the population doubling time of murine P388 leukemia cells in suspension culture and of B16 melanoma cells in monolayer culture. The suppression of the growth of P388 cells by geraniol (0-0.9 mM) and by mevinolin (0-0.25 microM), a competitive inhibitor of mevalonate biosynthesis, was reversed by the addition of 0.5 mM mevalonolactone to the growth medium. Flow cytometry of asynchronous B16 cells grown with geraniol (0-0.15 mM) revealed a population characterized by larger cells with altered nuclear characteristics. Over the course of four studies, dietary geraniol increased the 50% survival time of mice by 10, 29, 33, and 50% following the i.p. transfer of P388 cells. The results of the latter study showed that, following the i.p. transfer of 1 x 10(5) P388 cells, the control group of female C57BL x DBA/2 F1 mice had a 50% survival time of 24 days and a maximum survival of 27 days. Mice fed a diet containing 0.1% geraniol for 14 days prior to and following the P388 cell transfer had a 50% survival time of 36 days, and 20% of the mice remained free of tumors during the 50-day trial. These studies support the possibility that monoterpenes and other isoprenoid products of plant metabolism are in part responsible for the anticarcinogenic actions of diverse fruits, vegetables, and cereal products.
Authors:
S M Shoff; M Grummer; M B Yatvin; C E Elson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  51     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-02-27     Completed Date:  1991-02-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  37-42     Citation Subset:  IM    
Affiliation:
Department of Nutritional Sciences, University of Wisconsin, Madison 53706.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Division / drug effects
Growth Inhibitors
Leukemia, Experimental / drug therapy,  pathology*
Melanoma, Experimental / drug therapy,  pathology*
Mevalonic Acid / metabolism
Mice
Survival Analysis
Terpenes / pharmacology*,  therapeutic use
Tumor Cells, Cultured
Grant Support
ID/Acronym/Agency:
CA 09451/CA/NCI NIH HHS; HL 33893/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Growth Inhibitors; 0/Terpenes; 150-97-0/Mevalonic Acid; 624-15-7/geraniol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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