| Concentration-dependent absorption of aluminum in rats exposed to labile aluminum in drinking water. | |
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MedLine Citation:
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PMID: 10201636 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hypothesis was tested that the absorption of labile Al in rats will increase when the Al-binding capacity of food components in the stomach is saturated. Male rats were exposed to 0, 10, 50, or 500 mg labile Al/L in acidic drinking water (pH 3) for 9 wk. The results show that labile Al in drinking water is complexed by feed constituents in the stomach of the rat in vivo, thus causing a nondetectable absorption of Al at 10 mg Al/L. An increased absorption of Al at 50 and 500 mg Al/L was associated with a saturation of the Al-binding capacity of feed components in the lumen of the stomach, causing the appearance of labile Al. Thus, the presence of labile Al in drinking water does not necessarily result in a high Al absorption when the water is ingested, since the bioavailability of labile Al is dependent both on the amount and composition of Al-binding components present in the gastrointestinal tract at the time of ingestion of the water. It is thus not possible to predict the body burden of Al in humans just by measuring the Al concentrations in drinking water. Even a further refining of the exposure measurement to include speciation of Al in the water may not markedly improve the prediction of the Al body burden. Future epidemiological studies must therefore be based on actual measurements of Al concentration in tissues or fluids from the study subjects. |
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Authors:
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A W Glynn; A Sparén; L G Danielsson; B Sundström; L Jorhem |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of toxicology and environmental health. Part A Volume: 56 ISSN: 1528-7394 ISO Abbreviation: J. Toxicol. Environ. Health Part A Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-04-15 Completed Date: 1999-04-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100960995 Medline TA: J Toxicol Environ Health A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 501-12 Citation Subset: IM |
Affiliation:
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Swedish National Food Administration, Department of Environmental Toxicology, Uppsala University. wicklund-glynn.1@postbox.acs.ohio-state.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Administration, Oral Aluminum / analysis, metabolism*, pharmacokinetics Animals Body Burden Body Weight Bone and Bones / chemistry, metabolism* Dose-Response Relationship, Drug Drinking Eating Gastrointestinal Contents / chemistry Hydrogen-Ion Concentration Male Rats Rats, Sprague-Dawley Stomach / metabolism* Water / analysis, chemistry, metabolism* Water Pollutants, Chemical / analysis |
| Chemical | |
Reg. No./Substance:
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0/Water Pollutants, Chemical; 7429-90-5/Aluminum; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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