Document Detail


Concentration of adipokines in peritoneal effluent: a new marker of acute peritonitis in peritoneal dialysis patients?
MedLine Citation:
PMID:  18708547     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: An early and reliable diagnostic procedure for acute peritonitis in patients on peritoneal dialysis (PD) without typical clinical symptoms remains an important challenge in modern nephrology. During the first days of peritonitis, establishing the diagnosis based on peritoneal effluent pleocytosis and inflammatory markers [C-reactive protein (CRP) or interleukin-6] is not efficient in all cases. Increased peritoneal membrane permeability is a well-known consequence of peritonitis. Therefore, we evaluated the concentrations of selected circulating adipose tissue-derived proteins in the peritoneal effluent of PD patients with episodes of acute peritonitis.
MATERIAL AND METHODS: Concentrations of adiponectin and leptin, in both plasma and peritoneal effluent, were assessed in 24 adult PD patients with peritonitis episodes confirmed by clinical symptoms and/or microbiological tests, and in 23 PD patients without signs and symptoms of inflammation (control group).
RESULTS: In peritoneal effluent collected from patients with acute peritonitis (also without pleocytosis or increased CRP), both adiponectin and leptin concentrations were markedly elevated: adiponectin 744.1 (344.2 - 1144.1) ng/mL vs 4.8 (3.1 - 6.5) ng/mL; leptin 16.3 (9.4 - 23.1) ng/mL vs 5.1 (0.5 - 9.6) ng/mL. Receiver operating characteristic analyses revealed that peritoneal effluent adiponectin concentration >180 ng/mL has 100% sensitivity and 100% specificity, while peritoneal effluent leptin concentration >11.0 ng/mL has 58.3% sensitivity and 95.5% specificity for the diagnosis of acute peritonitis. The increases in adiponectin and leptin concentrations in peritoneal effluent were not consequences of changes in their plasma levels. A positive correlation between peritoneal effluent and plasma concentrations of adiponectin and leptin in patients with peritonitis was found.
CONCLUSION: Increased concentration of leptin and especially adiponectin in peritoneal effluent seems to be a valuable and new early marker of high peritoneal membrane permeability due to acute peritonitis.
Authors:
Aureliusz Kolonko; Jerzy Chudek; Andrzej Wiecek
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  28     ISSN:  0896-8608     ISO Abbreviation:  Perit Dial Int     Publication Date:    2008 Sep-Oct
Date Detail:
Created Date:  2008-08-18     Completed Date:  2009-01-15     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  527-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adiponectin / blood*
Adult
Aged
Biological Markers / blood*
Diabetic Nephropathies / blood,  therapy
Female
Humans
Kidney Failure, Chronic / blood*,  therapy
Leptin / blood*
Male
Middle Aged
Peritoneal Dialysis* / adverse effects
Peritonitis / blood,  diagnosis*,  etiology
ROC Curve
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Adiponectin; 0/Biological Markers; 0/Leptin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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