Document Detail


Concentration Polarization in Translocation of DNA through Nanopores and Nanochannels.
MedLine Citation:
PMID:  22540727     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
In this Letter we provide a theory to show that high-field electrokinetic translocation of DNA through nanopores or nanochannels causes large transient variations of the ionic concentrations in front and at the back of the DNA due to concentration polarization (CP). The CP causes strong local conductivity variations, which can successfully explain the nontrivial current transients and ionic distributions observed in molecular dynamics simulations of nanopore DNA translocations as well as the transient current dips and spikes measured for translocating hairpin DNA. Most importantly, as the future of sequencing of DNA by nanopore translocation will be based on time-varying electrical conductance, CP, must be considered in experimental design and interpretation-currently these studies are mostly based on the incomplete pore conductance models that ignore CP and transients in the electrical conductance.
Authors:
Siddhartha Das; Pavel Dubsky; Albert van den Berg; J C T Eijkel
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Publication Detail:
Type:  Journal Article     Date:  2012-03-26
Journal Detail:
Title:  Physical review letters     Volume:  108     ISSN:  1079-7114     ISO Abbreviation:  Phys. Rev. Lett.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-04-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401141     Medline TA:  Phys Rev Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  138101     Citation Subset:  IM    
Affiliation:
Physics of Fluids Group and J. M. Burgers Centre for Fluid Dynamics, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
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