Document Detail

Concanavalin A induces suppressor cell activity in both T gamma and T non-gamma cells: most of the suppressor cells do not carry HLA-DR antigens.
MedLine Citation:
PMID:  6461918     Owner:  NLM     Status:  MEDLINE    
Concanavalin A (Con A) stimulation of T lymphocytes for 48 h induced a dose-dependent increase in the percentage of T gamma cells, and proliferation of these cells was dependent on pre-existing T gamma cells. Con A stimulation also induced a dose-dependent increase in suppressor cell activity as measured in a Con A/mixed lymphocyte culture assay. Removal of T gamma cells before stimulation with Con A did not influence suppressor cell activity, whereas depletion of T gamma cells after Con A stimulation significantly reduced the suppression. Treatment of T lymphocytes with monoclonal anti-HLA-DR antibodies and complement significantly increased the percentage of T gamma cells and also increased the suppressor cell activity, both when the cells were treated before and when they were treated after Con A stimulation. Similarly, increased suppressor cell activity was also seen when T mu cells were removed. The results indicate that Con-A-induced suppressor cells are recruited from both T gamma and T non-gamma cells and also suggest that most of the Con-A-induced suppressor cell activity is exerted by HLA-DR-negative cells.
J H Dobloug; O Førre; C Chattopadhyay; J B Natvig
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  15     ISSN:  0300-9475     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-06-21     Completed Date:  1982-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  87-95     Citation Subset:  IM    
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MeSH Terms
Cell Separation
Concanavalin A / pharmacology*
Cytotoxicity Tests, Immunologic
Dose-Response Relationship, Immunologic
Histocompatibility Antigens Class II / immunology
Lymphocyte Activation*
Lymphocyte Culture Test, Mixed
Receptors, Antigen, B-Cell / immunology
Receptors, Fc
Rosette Formation
T-Lymphocytes / classification,  immunology*
T-Lymphocytes, Regulatory / immunology*
Reg. No./Substance:
0/Histocompatibility Antigens Class II; 0/Receptors, Antigen, B-Cell; 0/Receptors, Fc; 11028-71-0/Concanavalin A

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