Document Detail

Concanavalin-A binding sites, pemphigus antigens, and beta 2 microglobulin in epidermal hyperproliferation, premalignant and malignant lesions.
MedLine Citation:
PMID:  6187299     Owner:  NLM     Status:  MEDLINE    
Three cell surface parameters of epidermal cells have been studied by immunofluorescence, pemphigus antigens, concanavalin-A binding sugars, and beta 2 microglobulin. Biopsy specimens were taken from a total of 59 patients with psoriasis, seborrheic and solar keratosis, squamous cell carcinoma, and basal cell epithelioma. We found a loss of demonstrability of all parameters in dedifferentiated tumors or tumor areas in squamous cell carcinoma, premonitory changes in solar keratosis, and no changes in seborrheic keratosis. In the psoriatic epidermis a granular redistribution of the cell surface parameters was occasionally observed in circumscribed areas of the epidermis. A selective loss of the demonstrability of beta 2 microglobulin was the prominent feature in basal cell epithelioma. Our findings demonstrate that the alterations of the cell surface differ in malignant and premalignant skin tumors, in basal cell epithelioma, and in benign psoriatic hyperplasia.
G Mahrle; H Patyk; R Bolling
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of dermatological research     Volume:  274     ISSN:  0340-3696     ISO Abbreviation:  Arch. Dermatol. Res.     Publication Date:  1982  
Date Detail:
Created Date:  1983-04-07     Completed Date:  1983-04-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8000462     Medline TA:  Arch Dermatol Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  85-92     Citation Subset:  IM    
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MeSH Terms
Antigens / analysis*
Beta-Globulins / analysis*
Binding Sites
Carcinoma, Squamous Cell / immunology
Concanavalin A / metabolism*
Fluorescent Antibody Technique
Keratosis / immunology
Pemphigus / immunology*
Precancerous Conditions / immunology*
Psoriasis / immunology
Skin Neoplasms / immunology*
beta 2-Microglobulin / analysis*
Reg. No./Substance:
0/Antigens; 0/Beta-Globulins; 0/beta 2-Microglobulin; 11028-71-0/Concanavalin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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