| Computerized physician order entry of injectable antineoplastic drugs: an epidemiologic study of prescribing medication errors. | |
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MedLine Citation:
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PMID: 20829102 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: In the context of CPOE of standardized antineoplastic drugs, the objectives of the present study were to determine the incidence of prescribing medication errors (PME) and to analyse PME related to antineoplastic treatment in university teaching hospitals. METHODS: All consecutive prescribing medication orders over 1 year were analysed prospectively. Potential clinical impact was quoted according to the Hatoum scale and risk factors identified with a logistic-regression model. RESULTS: A total of 14,854 prescriptions were analysed. The PME incidence was estimated at 1.5% [1.3-1.7], i.e. 15 errors per 1000 prescribing medication orders, with a significant or very significant potential clinical impact in 62.9% of cases. Potentially death-threatening events were avoided in 3.7% of cases. Overall, PME incidence related to significant, very significant or vital potential clinical impact was estimated to be 1.0% [0.8-1.2], i.e. 10 errors per 1000 prescribing medication orders. The most common type of error was related to antineoplastic drug dosage (61.0%): inadequate adaptation (43.1%), not taking alarms into account (16.1%), incorrect weight (0.9%), incorrect unit (0.9%). More than 20% of PME are medication errors directly linked to the prescribing medication order (choice of antineoplastic treatment, double-prescribing medication order, forgotten or not validated by a resident or senior physician). Occasional users of the CPOE system and resident physicians were identified as main PME risk factors. CONCLUSION: An epidemiologic survey of PME in the context of the use of a partial CPOE has allowed to determine the incidence and epidemiology of PME as well as the potential clinical impact they represent. Two risk factors have emerged that can be considered from an organization and software points of view. Better pharmacist's analysis of prescribing medication order within the CPOE system could possibly minimize duplication of antineoplasic drugs and the vital clinical impact associated with overdosage. |
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Authors:
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V Nerich; S Limat; M Demarchi; C Borg; P S Rohrlich; E Deconinck; V Westeel; C Villanueva; M C Woronoff-Lemsi; X Pivot |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of medical informatics Volume: 79 ISSN: 1872-8243 ISO Abbreviation: Int J Med Inform Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-17 Completed Date: 2010-12-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9711057 Medline TA: Int J Med Inform Country: Ireland |
Other Details:
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Languages: eng Pagination: 699-706 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Pharmacy, Jean Minjoz University Teaching Hospital, Besançon, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antineoplastic Agents / administration & dosage* Female Humans Injections, Intravenous Male Medical Order Entry Systems* Medication Errors / statistics & numerical data* Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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