| Computerized measurement of heart rate variation in fetal anemia caused by rhesus alloimmunization. | |
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MedLine Citation:
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PMID: 1530024 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to examine the relationship between fetal heart rate variation and fetal hematocrit. STUDY DESIGN: In 36 red-cell alloimmunized pregnancies (mean gestational age 30, range 25 to 36 weeks) 65 computerized fetal heart rate recordings were obtained before ultrasonographically guided fetal blood sampling for the measurement of fetal hematocrit. The recordings were captured and analyzed by a microcomputer on-line. Fetal heart rate variation in anemic fetuses was accurately measured. RESULTS: Significant positive correlations between short-term or long-term heart rate variation and fetal hematocrit have been demonstrated even after adjusting for the effect of gestation (r = 0.60, n = 65, p less than 0.01, y = 19.264 + 0.913x - 0.003x2; r = 0.52, n = 65, p less than 0.01, y = 21.13 + 0.858x - 0.003x2, respectively). The relationship was best described by a quadratic model. When short-term variation was less than 5 milliseconds or long-term variation was less than 30 milliseconds, the positive predictive values for fetal hematocrit of less than 30 were 85% and 90%, and the negative predictive values 56% and 57%, respectively. CONCLUSION: Computerized recording and analysis of fetal heart rate variation may prove to be a useful noninvasive tool for assessing fetal anemia in red-cell alloimmunization. |
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Authors:
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D L Economides; M Selinger; J Ferguson; P J Bowell; G S Dawes; I Z Mackenzie |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 167 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1992 Sep |
Date Detail:
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Created Date: 1992-10-22 Completed Date: 1992-10-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 689-93 Citation Subset: AIM; IM |
Affiliation:
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Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, England. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia
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blood,
diagnosis,
immunology* Diagnosis, Computer-Assisted* Female Fetal Diseases / blood, diagnosis, immunology* Fetal Monitoring* Heart Rate* Hematocrit Humans Isoantigens / immunology* Predictive Value of Tests Pregnancy Rh-Hr Blood-Group System / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Isoantigens; 0/Rh-Hr Blood-Group System |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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