Document Detail


Computerized assessment of angiographic occlusion rate and coil density in embolized human cerebral aneurysms.
MedLine Citation:
PMID:  19299484     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Computerized methods have been introduced for more objective quantification of angiographic occlusion rate and coil density as parameters of successful embolization. This study aimed 1) to evaluate this new computerized method for angiographic occlusion rating and coil density calculations by comparison with corresponding histometric parameters from retrieved human aneurysms, and 2) to compare the new computerized method with the present standard of subjective angiographic occlusion rating. MATERIALS AND METHODS: From 14 postmortem-retrieved human aneurysms, angiographic occlusion rate was determined by contrast medium attenuation-gradient distinction on digital subtraction angiographs after Guglielmi detachable coil (GDC) embolization. Angiographic coil density was calculated, approximating aneurysms as ellipsoid and coils as cylindric volumes. On surface-stained histologic ground sections of the respective aneurysms, the occluded aneurysm area and coil area were measured. Then, we calculated and compared the histometric occlusion rates and coil densities with the corresponding angiographic parameters by using the Wilcoxon paired signed-rank test and the Spearman rank correlation. RESULTS: Computerized angiographic occlusion rates (75%-100%) showed good correlation (r = 0.799; P < .01) with histometric occlusion-rates (61%-100%), resulting in no statistically significant differences (P = .2163). With 5.1% (+/-3.8), the mean difference between computerized angiographic occlusion rates and histometry was substantially lower compared with 10.7% (+/-8.7) mean difference between subjective angiographic estimations and histometry. Calculated angiographic coil density (13%-32%) significantly differed from histometric coil density (8%-35%; P < .05). CONCLUSIONS: For recanalized aneurysms, computerized angiographic occlusion rating showed better correspondence with histometry compared with subjective angiographic occlusion rating. Clinical application of this new tool may lead to more objective cutoff values for re-embolization indications. The value of coil density calculations seems limited by the approximation of the aneurysms as ellipsoid volumes.
Authors:
C Sherif; G Bavinzski; C Dorfer; F Kanz; E Schuster; H Plenk
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2009-03-19
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  30     ISSN:  1936-959X     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-13     Completed Date:  2009-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1046-53     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Medical University Vienna, Vienna, Austria. camillo.sherif@meduniwien.ac.at
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Algorithms
Artificial Intelligence
Cerebral Angiography / methods*
Cerebrovascular Disorders / prevention & control*,  radiography*
Female
Humans
Intracranial Aneurysm / radiography*,  therapy*
Male
Middle Aged
Pattern Recognition, Automated / methods*
Radiographic Image Enhancement / methods
Radiographic Image Interpretation, Computer-Assisted / methods*
Reproducibility of Results
Sensitivity and Specificity
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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