Document Detail

Computerized EEG: predictor of outcome in schizophrenia.
MedLine Citation:
PMID:  1090708     Owner:  NLM     Status:  MEDLINE    
Based on a double blind cross-over study, it was determined that schizophrenic patient who have more high frequency fast activity and a lesser degree of alpha and slow waves in computerized EEG before the treatment have a better therapeutic outcome to the major tranquilizer (neuroleptic) treatment. The correlation between pretreatment high frequency computer EEG measurements and better therapeutic outcome reached the level of statistical significance. "Therapy resistant" schizophrenic patients were characterized by a lesser degree of very fast beta activity, more alpha waves and slow waves, higher amplitudes in computer EEG, and a lesser degree of acute (florid) psychotic symptomatology but more "negative" symptoms such as motor retardation and blunted affect. One of the most striking results of the study is the finding that schizophrenic patients with certain psychopathological profiles also have similar computer EEG profiles.
T M Itil; J Marasa; B Saletu; S Davis; A N Mucciardi
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of nervous and mental disease     Volume:  160     ISSN:  0022-3018     ISO Abbreviation:  J. Nerv. Ment. Dis.     Publication Date:  1975 Mar 
Date Detail:
Created Date:  1975-06-13     Completed Date:  1975-06-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375402     Medline TA:  J Nerv Ment Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  118-203     Citation Subset:  AIM; IM    
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MeSH Terms
Chronic Disease
Clinical Trials as Topic
Drug Resistance
Fluphenazine / therapeutic use
Haloperidol / therapeutic use
Middle Aged
Psychiatric Status Rating Scales
Schizophrenia / diagnosis,  drug therapy*
Schizophrenia, Disorganized / diagnosis,  drug therapy
Schizophrenia, Paranoid / diagnosis,  drug therapy
Thiothixene / therapeutic use
Reg. No./Substance:
0/Placebos; 52-86-8/Haloperidol; 5591-45-7/Thiothixene; 69-23-8/Fluphenazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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