Document Detail


Computer programs for calculation of median effective dose (LD50 or ED50) using the method of moving average interpolation.
MedLine Citation:
PMID:  8085946     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over the past 40 years, toxicologists and pharmacologists have used tables published by Weil for the determination of LD50 (or ED50) values and their associated 95% confidence intervals. With the advances in computer technology, it is now common for investigators to have personal computers in their laboratories. Therefore, two identical programs were developed for determination of the LD50 (or ED50) which may be run on a personal computer. One of these programs was written in BASIC, and the other in FORTRAN. The programs are easy and rapid to use, requiring minimum computer hardware and little, if any, knowledge of programming. They also offer more user flexibility than the previously published tables of Weil, in that there are fewer restrictions on the number of animals and number of dosage levels used in an experiment. The output of the programs may be typed on the screen of a computer monitor, and may be sent to a printer. The two programs calculate the LD50 and 95% confidence intervals for the LD50. These programs should be valuable for many investigators.
Authors:
M M Schaper; R D Thompson; C S Weil
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of toxicology     Volume:  68     ISSN:  0340-5761     ISO Abbreviation:  Arch. Toxicol.     Publication Date:  1994  
Date Detail:
Created Date:  1994-10-13     Completed Date:  1994-10-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0417615     Medline TA:  Arch Toxicol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  332-7     Citation Subset:  IM    
Affiliation:
University of Pittsburgh, Graduate School of Public Health, Center for Environmental and Occupational Health and Toxicology, PA 15238.
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MeSH Terms
Descriptor/Qualifier:
Dose-Response Relationship, Drug*
Lethal Dose 50
Mathematical Computing
Programming Languages
Software*
Grant Support
ID/Acronym/Agency:
R01-ES02747/ES/NIEHS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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