Document Detail


Computer models of albumin and haemoglobin glycation.
MedLine Citation:
PMID:  2249425     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two first-order mathematical models were developed to mimic the glycation of haemoglobin (H) and albumin (A). The total concentrations of A and H were assumed to be constant. The responses of the two models to varying blood glucose level were compared. The parameters of the haemoglobin model were not numerically estimated, only an informal fit was performed using clinical and published data. Nonlinear regression analysis was used to estimate the parameters of the albumin model. The level of glycated A (GA) was derived from the measured fructosamine level. Three diabetics were monitored daily for the level of fructosamine and blood glucose profile over a period of 10, 16 and 21 days, respectively. Conclusions: (1) The difference between GA and glycated H (GH) resulting from different elimination rates is decreased by the stratification of erythrocyte population. (2) Both GA and GH seem to have higher elimination rates than their nonglycated equivalents.
Authors:
S Svacina; R Hovorka; J Skrha
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Computer methods and programs in biomedicine     Volume:  32     ISSN:  0169-2607     ISO Abbreviation:  Comput Methods Programs Biomed     Publication Date:    1990 Jul-Aug
Date Detail:
Created Date:  1991-01-17     Completed Date:  1991-01-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8506513     Medline TA:  Comput Methods Programs Biomed     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  259-63     Citation Subset:  IM    
Affiliation:
3rd Department of Medicine, Charles University, Prague, Czechoslovakia.
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MeSH Terms
Descriptor/Qualifier:
Blood Glucose / metabolism
Computer Simulation*
Diabetes Mellitus, Type 1 / metabolism
Fructosamine
Glycosylation
Half-Life
Hemoglobin A, Glycosylated / metabolism*
Hexosamines / metabolism
Humans
Models, Biological*
Monitoring, Physiologic
Obesity / metabolism
Serum Albumin / metabolism*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/Hexosamines; 0/Serum Albumin; 0/glycosylated serum albumin; 4429-04-3/Fructosamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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