Document Detail

Computer modeling of acceleration effects on cerebral oxygen saturation.
MedLine Citation:
PMID:  16110688     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Failure to effectively regulate BP and cerebral perfusion during high-G aircraft maneuvering may contribute to reduced performance in pilots due to the fact that perfusion to the peripheral cerebral tissues may not be adequate to support the mental demands of flight. Therefore, a critical area of investigation is the study of cortical tissue oxygenation responses to +Gz acceleration. METHODS: Two experiments were used to build two sections of a cerebral oxygen saturation (rSo2) model. Experiment 1: Six subjects participated in the study. A cerebral oximeter (gold standard) provided rSo2. Acceleration profiles (subjects relaxed) included a 0.1 G x s(-1) G onset to central light loss (CLL) and a 3 G x s(-1) onset to a G level that was 1 Gz above CLL to an endpoint of G-LOC. Experiment 2: There were 12 subjects (with G protection) who participated in this study. The rSo2 data were collected during five different simulated aerial combat maneuvers. A model was created that read the Gz profile as input and calculated changes in rSo2. The correlation coefficient, linear best-fit slope, and mean percent error were calculated to determine agreement. RESULTS: The average value for the correlation coefficients, linear best-fit slopes, and mean percent errors for the unprotected subjects were 0.79, 0.87, and 6.08, respectively. These values for the protected subjects were 5 G (0.994, 1.011, 0.384), 6 G (0.994, 0.909, 0.811), 7 G (0.986, 1.061, 0.692), 8 G (0.969, 1.016, 1.300), and 9 G (0.994, 0.979, 0.558), respectively. DISCUSSION: The model is a good predictor of rSo2 values for protected and unprotected subjects under +Gz stress.
Richard A McKinley; Lloyd D Tripp; Steve D Bolia; Marvin R Roark
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  76     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-22     Completed Date:  2005-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  733-8     Citation Subset:  IM; S    
Aircrew Performance and Protection Branch, Air Force Research Laboratory, 2215 First St., Bldg. 33, Wright-Patterson AFB, OH 45433-7947, USA.
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MeSH Terms
Brain / blood supply*
Computer Simulation*
Gravity Suits
Oxygen / analysis*
Regional Blood Flow
Reg. No./Substance:

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