Document Detail

Computer model of nucleotide transport in a realistic porcine aortic trifurcation.
MedLine Citation:
PMID:  18415019     Owner:  NLM     Status:  MEDLINE    
Adenosine triphosphate (ATP) is a ubiquitous blood borne agonist which is responsible for the regulation of vascular tone via purinogenic signalling pathways. The present study models the transport of ATP in a realistic porcine aortic trifurcation, which includes multiple branches and bifurcations. The focus of the present study is understanding how pulsatile flow effects mass transfer, observing both mean and transient variations. Unlike in the many idealized models which model transport of low diffusion coefficient species, the realistic geometry leads to very different mass transfer characteristics. These include spiral patterns in the distribution of low concentration fluid. Furthermore, the mean ATP distribution was found to be elevated compared with the steady state; this is attributed to the effects of convective mixing. The results strongly implicate that under certain conditions mass transport in pulsatile flow exhibits different hydrolysis characteristics at the endothelium compared with steady state. Transient variations throughout the the cardiac cycle were found to be small. This small transient response is primarily due to low ATP diffusivity.
Andrew Comerford; Tim David
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Publication Detail:
Type:  Journal Article     Date:  2008-04-15
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  36     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-05-29     Completed Date:  2008-06-27     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1175-87     Citation Subset:  IM    
Technical University of Munich, Boltzmannstrasse 15, Garching, 85747, Germany.
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MeSH Terms
Adenosine Triphosphate / metabolism*
Aorta / physiology*
Biological Transport, Active / physiology
Blood Flow Velocity / physiology
Blood Pressure / physiology
Computer Simulation
Models, Cardiovascular*
Rheology / methods*
Reg. No./Substance:
56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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