| Computer model of nucleotide transport in a realistic porcine aortic trifurcation. | |
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MedLine Citation:
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PMID: 18415019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adenosine triphosphate (ATP) is a ubiquitous blood borne agonist which is responsible for the regulation of vascular tone via purinogenic signalling pathways. The present study models the transport of ATP in a realistic porcine aortic trifurcation, which includes multiple branches and bifurcations. The focus of the present study is understanding how pulsatile flow effects mass transfer, observing both mean and transient variations. Unlike in the many idealized models which model transport of low diffusion coefficient species, the realistic geometry leads to very different mass transfer characteristics. These include spiral patterns in the distribution of low concentration fluid. Furthermore, the mean ATP distribution was found to be elevated compared with the steady state; this is attributed to the effects of convective mixing. The results strongly implicate that under certain conditions mass transport in pulsatile flow exhibits different hydrolysis characteristics at the endothelium compared with steady state. Transient variations throughout the the cardiac cycle were found to be small. This small transient response is primarily due to low ATP diffusivity. |
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Authors:
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Andrew Comerford; Tim David |
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Publication Detail:
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Type: Journal Article Date: 2008-04-15 |
Journal Detail:
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Title: Annals of biomedical engineering Volume: 36 ISSN: 1521-6047 ISO Abbreviation: Ann Biomed Eng Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-05-29 Completed Date: 2008-06-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 1175-87 Citation Subset: IM |
Affiliation:
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Technical University of Munich, Boltzmannstrasse 15, Garching, 85747, Germany. comerford@lnm.mw.tum.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism* Animals Aorta / physiology* Biological Transport, Active / physiology Blood Flow Velocity / physiology Blood Pressure / physiology Computer Simulation Models, Cardiovascular* Rheology / methods* Swine |
| Chemical | |
Reg. No./Substance:
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56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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