| Computer graphic study on models of the molybdenum cofactor of xanthine oxidase. | |
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MedLine Citation:
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PMID: 3505588 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Within the scope of our molecular modeling studies on xanthine oxidase (XOD) inhibition by purine analogs we were interested to build up a three-dimensional model of the molybdenum active site. Spectroscopic data indicated that a Mo (VI)atom which is coordinated to sulfur, oxygen and/or nitrogen is clearly involved in substrate binding. In the present study, those data and X-ray crystallography data were used to reconstruct molybdenum-organic complexes from models proposed in the literature. The computer graphic-assisted modeling and evaluation of the model complexes show that the description of the molybdenum center needs further refinement. |
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Authors:
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G Folkers; M Krug; S Trumpp |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of computer-aided molecular design Volume: 1 ISSN: 0920-654X ISO Abbreviation: J. Comput. Aided Mol. Des. Publication Date: 1987 Apr |
Date Detail:
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Created Date: 1989-03-06 Completed Date: 1989-03-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8710425 Medline TA: J Comput Aided Mol Des Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 87-94 Citation Subset: IM |
Affiliation:
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Pharmaceutical Institute, University of Tübingen, F.R.G. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Binding Sites Coenzymes* Computer Graphics Metalloproteins* Models, Molecular* Pteridines* Xanthine Oxidase* |
| Chemical | |
Reg. No./Substance:
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0/Coenzymes; 0/Metalloproteins; 0/Pteridines; 73508-07-3/molybdenum cofactor; EC 1.17.3.2/Xanthine Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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