Document Detail


Computer-controlled electrical stimulation for quantitative mapping of human cortical function.
MedLine Citation:
PMID:  19061348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cortical mapping with electrical stimulation (ES) in neurosurgical patients typically involves the manually controlled delivery of suprathreshold electrical current to a discrete area of the brain. Limited numbers of trials and imprecise current delivery methods increase the variability of the behavioral response and make it difficult to collect quantitative mapping data, which is especially important in research studies of human cortical function. To overcome these limitations, the authors developed a method for computer-controlled delivery of defined electrical current to implanted intracranial electrodes. They demonstrate that stimulation can be time locked to a behavioral task to rapidly and systematically measure the detection threshold for ES in human visual cortex over many trials. Computer-controlled ES is well suited for the systematic and quantitative study of the function of virtually any region of cerebral cortex. It may be especially useful for studying human cortical regions that are not well characterized and for verifying the presence of stimulation-evoked percepts that are difficult to objectively confirm.
Authors:
Mario F Dulay; Dona K Murphey; Ping Sun; Yadin B David; John H R Maunsell; Michael S Beauchamp; Daniel Yoshor
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  110     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-02     Completed Date:  2009-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1300-3     Citation Subset:  AIM; IM    
Affiliation:
Departments of Neurosurgery, Texas Children's Hospital, Houston Texas, USA.
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MeSH Terms
Descriptor/Qualifier:
Brain Mapping / methods*
Electric Stimulation / methods*
Electrodes, Implanted
Epilepsy / physiopathology*,  psychology,  surgery
Humans
Reproducibility of Results
Signal Detection, Psychological*
Signal Processing, Computer-Assisted*
Task Performance and Analysis
Visual Cortex / physiopathology*
Grant Support
ID/Acronym/Agency:
NS045053/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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