Document Detail


Computer-based methods for measurement, recording and modeling vessel responses in vitro: a pilot study with noradrenaline.
MedLine Citation:
PMID:  12949629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper reports the first results of an ongoing methodological pilot study aimed at designing techniques for the automatic measurement and digital recording of vessel responses to biologically active substances under in vitro conditions and for the mathematical modeling of the underlying processes. The techniques presented in this pilot study allowed us to determine model-based estimates of the parameters characterizing vasoconstrictor responses, i.e., the vessel sensitivity parameter, the mean time of vasoconstrictor response and the rate constant of vessel relaxation. The given parameters are not dependent on doses of biologically active substances, provided that the underlying processes satisfy the principle of superposition. Use of these techniques is shown in the classic study of vasoconstrictor responses to noradrenaline in the rat renal artery.
Authors:
L Dedík; M Durisová; V Svrcek; R Vojtko; V Kristová; Milan Kriska
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Methods and findings in experimental and clinical pharmacology     Volume:  25     ISSN:  0379-0355     ISO Abbreviation:  Methods Find Exp Clin Pharmacol     Publication Date:    2003 Jul-Aug
Date Detail:
Created Date:  2003-09-01     Completed Date:  2004-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909595     Medline TA:  Methods Find Exp Clin Pharmacol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  441-45     Citation Subset:  IM    
Affiliation:
Faculty of Mechanical Engineering, Slovak University of Technology, Bratislava, Slovak Republic.
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MeSH Terms
Descriptor/Qualifier:
Animals
Computer Simulation
Male
Models, Biological
Norepinephrine / metabolism,  pharmacology*
Pilot Projects
Rats
Rats, Wistar
Renal Artery / drug effects*,  physiology
Time Factors
Vasoconstriction / drug effects
Vasoconstrictor Agents / metabolism,  pharmacology*
Chemical
Reg. No./Substance:
0/Vasoconstrictor Agents; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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