| Computer assisted recognition and quantitation of the effects of airborne chemicals acting at different areas of the respiratory tract in mice. | |
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MedLine Citation:
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PMID: 7802589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pattern and timing of a normal breath in unanesthetized mice was analyzed from measurement of inspiratory and expiratory airflows (VI and VE). Airflow was measured via a differential pressure transducer, attached to a pneumotachograph, which itself was attached to a body plethysmograph into which a mouse was placed. The analog voltage from the differential pressure transducer was digitized and stored for analysis on a microcomputer. Criteria were developed to classify each breath as normal (N) or belonging into one of seven abnormal categories. The abnormal categories were arrived at by computer analysis, recognizing specific modifications of the normal pattern into patterns of: sensory irritation of the upper respiratory tract (S), airflow limitation within the conducting airways of the lungs (A) or pulmonary irritation at the alveolar level (P). Combinations of these effects, i.e., S+A, P+A, P+S and P+S+A were also recognized. Computer analysis of each breath also permitted quantitative evaluation of the degree of S, A or P abnormalities. To induce each type of effect we used inhalation exposures to 2-chlorobenzylchloride, carbamylcholine or propranolol. We propose that this approach will permit rapid evaluation of the possible effects of airborne chemicals at three levels of the respiratory tract, with the classification of the type of effect easily obtained in an objective way using well defined criteria, followed by quantitation of the degree of each effect. |
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Authors:
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R Vijayaraghavan; M Schaper; R Thompson; M F Stock; L A Boylstein; J E Luo; Y Alarie |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of toxicology Volume: 68 ISSN: 0340-5761 ISO Abbreviation: Arch. Toxicol. Publication Date: 1994 |
Date Detail:
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Created Date: 1995-01-23 Completed Date: 1995-01-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0417615 Medline TA: Arch Toxicol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 490-9 Citation Subset: IM |
Affiliation:
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Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15238. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Aerosols Animals Benzyl Compounds / administration & dosage, toxicity* Carbachol / administration & dosage, toxicity* Computer Simulation Dose-Response Relationship, Drug Female Male Mice Microcomputers Plethysmography, Whole Body Propranolol / administration & dosage, toxicity* Pulmonary Alveoli / drug effects Pulmonary Ventilation / drug effects* Reference Standards Respiratory System / drug effects*, metabolism Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01-ESO2747/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 0/Benzyl Compounds; 51-83-2/Carbachol; 525-66-6/Propranolol; 611-19-8/2-chlorobenzyl chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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