Document Detail

Computer-assisted evaluation of dipyridamole thallium-201 SPECT in patients with aortic stenosis.
MedLine Citation:
PMID:  8195885     Owner:  NLM     Status:  MEDLINE    
Dipyridamole SPECT detects significant coronary artery disease (CAD) in patients without aortic stenosis. This study was done to establish normal 201Tl distribution limits in patients with aortic stenosis and to apply these normal limits to patients with aortic stenosis and angiographically significant CAD (> or = 75% area reduction). METHODS: Fifty-two patients (mean age 68 yr; mean valve area 0.67 cm2) were examined with 201Tl SPECT after dipyridamole infusion (0.56 mg/kg during 4 min). After tomographic reconstruction, basal, mid-ventricular and apical short-axis slices were selected. The highest activity in each six-degree segment was normalized to the maximal activity of each slice. RESULTS: Significant CAD was found in 24 patients. Five patients without CAD, but with localized hypokinesia or left bundle-branch block, were excluded from the reference group which finally consisted of 16 patients. Sensitivity for CAD was 88% when the lowest relative activity in each segment was used as the lower limit of normal. With -2 s.d. and -2.5 s.d. curves the sensitivity was 83% and 75%, respectively. Gender-specific limits were not used. Nonsignificant CAD was found in seven patients (< 75% stenoses). CONCLUSIONS: This study presents the normal distribution of 201Tl uptake for patients with aortic stenosis, using dipyridamole SPECT. The range method had the highest sensitivity for detection of significant CAD.
P Rask; K Karp; B Edlund; P Eriksson; T Mooe; U Wiklund
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  35     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-06-30     Completed Date:  1994-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  983-8     Citation Subset:  IM    
Department of Clinical Physiology, University Hospital of Northern Sweden, Umeå.
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MeSH Terms
Aortic Valve Stenosis / complications,  radiography,  radionuclide imaging*,  ultrasonography
Coronary Angiography
Coronary Disease / complications,  radiography,  radionuclide imaging
Dipyridamole / diagnostic use*
Image Processing, Computer-Assisted*
Middle Aged
Radionuclide Angiography
Sensitivity and Specificity
Thallium Radioisotopes / diagnostic use*
Tomography, Emission-Computed, Single-Photon*
Reg. No./Substance:
0/Thallium Radioisotopes; 58-32-2/Dipyridamole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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