Document Detail


Computer-assisted diagnostic system for neurodegenerative dementia using brain SPECT and 3D-SSP.
MedLine Citation:
PMID:  19148640     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To develop a computer-assisted automated diagnostic system to distinguish among Alzheimer disease (AD), dementia with Lewy bodies (DLB), and other degenerative disorders in patients with mild dementia. METHODS: Single photon emission computed tomography (SPECT) images with injection of N-Isopropyl-p-[(123)I]iodoamphetamine (IMP) were obtained from patients with mild degenerative dementia. First, datasets from 20 patients mild AD, 15 patients with dementia with DLB, and 17 healthy controls were used to develop an automated diagnosing system based on three-dimensional stereotactic surface projections (3D-SSP). AD- and DLB-specific regional templates were created using 3D-SSP, and critical Z scores in the templates were established. Datasets from 50 AD patients, 8 DLB patients, and 10 patients with non-AD/DLB type degenerative dementia (5 with frontotemporal dementia and 5 with progressive supranuclear palsy) were then used to test the diagnostic accuracy of the optimized automated system in comparison to the diagnostic interpretation of conventional IMP-SPECT images. These comparisons were performed to differentiate AD and DLB from non-AD/DLB and to distinguish AD from DLB. A receiver operating characteristic (ROC) analysis was performed. RESULTS: The area under the ROC curve (Az) and the accuracy of the automated diagnosis system were 0.89 and 82%, respectively, for AD/DLB vs. non-AD/DLB patients, and 0.70 and 65%, respectively, for AD vs. DLB patients. The mean Az and the accuracy of the visual inspection were 0.84 and 77%, respectively, for AD/DLB vs. non-AD/DLB patients, and 0.70 and 65%, respectively, for AD vs. DLB patients. The mean Az and the accuracy of the combination of visual inspection and this system were 0.96 and 91%, respectively, for AD/DLB vs. non-AD/DLB patients, and 0.70 and 66%, respectively, for AD vs. DLB patients. CONCLUSION: The system developed in the present study achieved as good discrimination of AD, DLB, and other degenerative disorders in patients with mild dementia as the commonly performed visual inspection of conventional SPECT images. A combination of visual inspection and this system is helpful in the differential diagnosis of patients with mild dementia.
Authors:
Kazunari Ishii; Tomonori Kanda; Takafumi Uemura; Naokazu Miyamoto; Toshiki Yoshikawa; Kenichi Shimada; Shingo Ohkawa; Satoshi Minoshima
Publication Detail:
Type:  Journal Article     Date:  2009-01-16
Journal Detail:
Title:  European journal of nuclear medicine and molecular imaging     Volume:  36     ISSN:  1619-7089     ISO Abbreviation:  Eur. J. Nucl. Med. Mol. Imaging     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-10     Completed Date:  2009-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140988     Medline TA:  Eur J Nucl Med Mol Imaging     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  831-40     Citation Subset:  IM    
Affiliation:
Department of Radiology and Nuclear Medicine, Hyogo Brain and Heart Center, Himeji, Hyogo, Japan. kishii@hbhc.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / diagnosis*,  radionuclide imaging*
Automation
Cerebrovascular Circulation
Dementia / diagnosis*,  radionuclide imaging*
Diagnosis, Computer-Assisted / methods*
Diagnosis, Differential
Humans
Imaging, Three-Dimensional
Iofetamine / pharmacology
Middle Aged
Neurodegenerative Diseases / diagnosis*,  radionuclide imaging*
ROC Curve
Radiopharmaceuticals / pharmacology
Tomography, Emission-Computed, Single-Photon / methods*
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 95896-48-3/Iofetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Biological nitrate removal in industrial wastewater treatment: which electron donor we can choose.
Next Document:  Which is more invasive-mini versus standard incisions in total hip arthroplasty?