Document Detail

Computer analysis of the tonic, phasic, and kinesthetic activity of pallidal discharges in Parkinson patients.
MedLine Citation:
PMID:  10369237     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Intraoperative analysis of microrecording data during pallidotomy often depends on subjective interpretation of the oscilloscope signal, especially during the analysis of phasic activity. The goals of this project were: 1) to develop an inexpensive system that allowed on-line, objective characterization of single-unit pallidal discharges, and 2) to have objective criteria to differentiate the internal part (GPi) from the external part (GPe) of the globus pallidus. METHODS: A computer program was developed that allowed the analysis of firing rates (mean, median, and quartiles), spike count per unit time, and interspike interval (ISI) histograms with Chi-square statistical evaluation. Indices were developed that measured phasic activity, including burst index (BI) for the measurement of bursts, pause index (PI) for the measurement of pauses, and pause ratio (PR) for analysis of time spent in pauses. Single-unit activity of 152 GPe and 203 GPi cells in 47 Parkinson patients were digitized using the computer soundcard during pallidotomy and analyzed using this software. RESULTS: GPe discharges had a mean firing rate = 42 Hz, BI = 0.81, PI = 0.21, and PR = 1.41. GPi had a mean firing rate = 81, BI = 1.61, PI = 0.04, and PR = 0.21. The PR was the best index that differentiated GPe from GPi, followed by PI, BI, and firing rates, in that order. Kinesthetic cells were recorded equally in GPe from GPi, and their responses to generalized movements were not significantly different. CONCLUSION: (1) Signal analysis using the digitization process of a computer sound card and dedicated software is satisfactory for the objective "on-line" and "off-line" analysis of microrecordings (including phasic activity); (2) PI and PR are most helpful in differentiating neurons of GPi from those of GPe; (3) no single parameter can differentiate GPe from GPi activity in all cases; and (4) unlike the findings in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys, GPe and GPi of Parkinson patients have similar prevalence of kinesthetic cells and similar responses to generalized somatotopic effects.
J Favre; J M Taha; T Baumann; K J Burchiel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgical neurology     Volume:  51     ISSN:  0090-3019     ISO Abbreviation:  Surg Neurol     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-06-23     Completed Date:  1999-06-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0367070     Medline TA:  Surg Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  665-72; discussion 672-3     Citation Subset:  IM    
Division of Neurosurgery, Oregon Health Sciences University, Portland, USA.
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MeSH Terms
Globus Pallidus / physiopathology*,  surgery*
Middle Aged
Monitoring, Intraoperative / instrumentation
Parkinson Disease, Secondary / physiopathology*,  surgery*
Signal Processing, Computer-Assisted
Stereotaxic Techniques

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