Document Detail


Computer analysis of intraarterially recorded blood pressure in conscious unrestrained rats.
MedLine Citation:
PMID:  3999759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A precise knowledge of cardiovascular activity and its pharmacological modifications in the conscious unrestrained animal requires intraarterial blood pressure recording for long periods of time. For that purpose, a technique was developed involving chronic catheterization of the rat abdominal aorta and the use of a computer system to perform the digitization of the blood pressure signal and the on-line calculation of five cardiovascular parameters. By means of duplexing, two rats (one treated and one control) can be studied simultaneously. Off-line processing is devoted to the graphic treatment and statistical analysis of the data. The effects of a single intravenous administration of dihydralazine are presented in order to show the usefulness of the technique.
Authors:
C Cerutti; C Barres; C Z Paultre; J Sassard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pharmacological methods     Volume:  13     ISSN:  0160-5402     ISO Abbreviation:  J Pharmacol Methods     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-07-25     Completed Date:  1985-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806596     Medline TA:  J Pharmacol Methods     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  249-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / physiology
Blood Pressure / drug effects
Blood Pressure Determination / instrumentation*
Cardiovascular Agents / pharmacology
Computers
Dihydralazine / pharmacology
Heart Rate / drug effects
Male
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Cardiovascular Agents; 484-23-1/Dihydralazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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