Document Detail

Computer-aided simple triage (CAST) for coronary CT angiography (CCTA).
MedLine Citation:
PMID:  22484719     Owner:  NLM     Status:  Publisher    
PURPOSE: Following a recent introduction of computer-aided simple triage (CAST) as a new subclass of computer-aided detection/diagnosis (CAD), we present a CAST software system for a fully automatic initial interpretation of coronary CT angiography (CCTA). We show how the system design and diagnostic performance make it CAST-compliant and suitable for chest pain patient triage in emergency room (ER). METHODS: The processing performed by the system consists of three major steps: segmentation of coronary artery tree, labeling of major coronary arteries, and detection of significant stenotic lesions (causing > 50% stenosis). In addition, the system performs an automatic image quality assessment to discards low-quality studies. For multiphase studies, the system automatically chooses the best phase for each coronary artery. Clinical evaluation results were collected in 14 independent trials that included more than 2000 CCTA studies. Automatic diagnosis results were compared with human interpretation of the CCTA and to cath lab results. RESULTS: The presented system performs a fully automatic initial interpretation of CCTA without any human interaction and detects studies with significant coronary artery disease. The system demonstrated higher than 90% per patient sensitivity and 40-70% per patient specificity. For the chest pain, ER population, the specificity was 60-70%, yielding higher than 98% NPV. CONCLUSIONS: The diagnostic performance of the presented CCTA CAD system meets the CAST requirements, thus enabling efficient, 24/7 utilization of CCTA for chest pain patient triage in ER. This is the first fully operational, clinically validated, CAST-compliant CAD system for a fully automatic analysis of CCTA and detection of significant stenosis.
Roman Goldenberg; Dov Eilot; Grigory Begelman; Eugene Walach; Eyal Ben-Ishai; Nathan Peled
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-7
Journal Detail:
Title:  International journal of computer assisted radiology and surgery     Volume:  -     ISSN:  1861-6429     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101499225     Medline TA:  Int J Comput Assist Radiol Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Rcadia Medical Imaging, 157 Yafo str, 35251, Haifa, Israel,
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