Document Detail

Computer activities, physical exercise, aging, and mild cognitive impairment: a population-based study.
MedLine Citation:
PMID:  22560523     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the association between computer use, physical exercise, aging, and mild cognitive impairment (MCI).
PATIENTS AND METHODS: The Mayo Clinic Study of Aging is a population-based study of aging and MCI in Olmsted County, Minnesota. The study sample consists of a random sample of 926 nondemented individuals aged 70 to 93 years who completed self-reported questionnaires on physical exercise, computer use, and caloric intake within 1 year of the date of interview. The study was conducted from April 1, 2006, through November 30, 2008. An expert consensus panel classified each study participant as cognitively normal or having MCI on the basis of published criteria.
RESULTS: Using a multivariable logistic regression model, we examined the impact of the presence during the study period of 2 lifestyle factors (physical exercise and computer use) after adjusting for a third lifestyle factor (caloric intake) on aging and MCI. We also adjusted for age, sex, education, medical comorbidity, and depression. The median daily caloric intake was significantly higher in participants with MCI than in controls (odds ratio, 1.04; 95% confidence interval, 1.02-1.06; P=.001). Participants who engaged in both moderate physical exercise and computer use had significantly decreased odds of having MCI (odds ratio [95% confidence interval], 0.36 [0.20-0.68]) compared with the reference group. In the interaction analyses, there was an additive interaction (P=.012) but not multiplicative interaction (P=.780).
CONCLUSION: In this population-based sample, the presence of both physical exercise and computer use as assessed via survey was associated with decreased odds of having MCI, after adjustment for caloric intake and traditional confounders.
Yonas E Geda; Taryn C Silber; Rosebud O Roberts; David S Knopman; Teresa J H Christianson; V Shane Pankratz; Bradley F Boeve; Eric G Tangalos; Ronald C Petersen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mayo Clinic proceedings     Volume:  87     ISSN:  1942-5546     ISO Abbreviation:  Mayo Clin. Proc.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-07     Completed Date:  2012-07-03     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  0405543     Medline TA:  Mayo Clin Proc     Country:  England    
Other Details:
Languages:  eng     Pagination:  437-42     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Activities of Daily Living
Aged, 80 and over
Attitude to Computers*
Attitude to Health
Energy Intake*
Geriatric Assessment / statistics & numerical data
Health Status*
Mild Cognitive Impairment / diagnosis*,  epidemiology*
Odds Ratio
Population Surveillance
Regression Analysis
Retrospective Studies
Grant Support
K01 AG028573/AG/NIA NIH HHS; K01 AG028573/AG/NIA NIH HHS; K01 AG028573-03/AG/NIA NIH HHS; K01 MH068351/MH/NIMH NIH HHS; K01 MH068351/MH/NIMH NIH HHS; P50 AG016574/AG/NIA NIH HHS; R01 AG034676/AG/NIA NIH HHS; R01 AR030582/AR/NIAMS NIH HHS; R01 NS033978/NS/NINDS NIH HHS; RR024150/RR/NCRR NIH HHS; U01 AG006786/AG/NIA NIH HHS; U01 AG006786/AG/NIA NIH HHS; U01 AG006786-21/AG/NIA NIH HHS

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