Document Detail


Computed tomography with histopathologic correlation in children with leukokoria.
MedLine Citation:
PMID:  6726555     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Computed tomography (CT) constitutes a major advance in noninvasive diagnostic investigation of children with leukokoria , especially where media opacities preclude adequate visualization of the posterior segment, and, performed in conjunction with other studies such as diagnostic ultrasonography, has significantly improved diagnostic accuracy. Although retinoblastoma, the commonest life-threatening cause of leukokoria , usually presents with characteristic CT findings of intraocular calcification, during extraocular extension, the orbital portions of the tumor are non-calcific and contrast dramatically with the intraocular portion. Currently CT is also the best available technique for diagnosis of trilateral retinoblastoma. Computed tomographic features of several types of pseudogliomas (a collective term for lesions commonly mistaken for retinoblastomas) are also discussed with histopathologic correlation. In persistent hyperplastic primary vitreous, a conical density in CT corresponded to detached and dysplastic retina. A high density layered opacity corresponded to subretinal blood. In Coats' disease and sclerosing endophthalmitis homogenous intraocular CT density corresponds to vitreous and subretinal exudates radiologically indistinguishable from non-calcific retinoblastoma. Long-standing retinal detachments in children occasionally presenting with leukokoria showed subtle homogenous intraocular densities on CT.
Authors:
N N Katz; C E Margo; R H Dorwart
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of pediatric ophthalmology and strabismus     Volume:  21     ISSN:  0191-3913     ISO Abbreviation:  J Pediatr Ophthalmol Strabismus     Publication Date:    1984 Mar-Apr
Date Detail:
Created Date:  1984-07-09     Completed Date:  1984-07-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7901143     Medline TA:  J Pediatr Ophthalmol Strabismus     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  50-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Child, Preschool
Diagnosis, Differential
Eye / pathology
Eye Diseases / pathology,  radiography
Eye Neoplasms / pathology,  radiography*
Female
Humans
Infant
Male
Retinoblastoma / pathology,  radiography*
Tomography, X-Ray Computed*
Grant Support
ID/Acronym/Agency:
EY 070 40/EY/NEI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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