| Computed tomography, positron emission tomography, positron emission tomography/computed tomography, and magnetic resonance imaging for staging of limited pleural mesothelioma: initial results. | |
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MedLine Citation:
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PMID: 18791416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate and compare the role of computed tomography (CT), positron emission tomography (PET), PET/CT, and magnetic resonance imaging (MRI) in the correct staging of patients with limited malignant pleural mesothelioma (MPM). MATERIALS AND METHODS: Fifty-four patients with an epithelial MPM (34 men and 20 women) were included in this study. Patients were referred to our department for staging in a predicted resectable state (stage II/III). Within 3 days, PET/CT and MRI was performed in all patients. Images were evaluated by 3 specialists in the field of PET/CT and MRI. The subexaminations of PET/CT, PET, and CT were independently evaluated with respect to tumor stage. Subexaminations were compared with each other, with MRI and PET/CT. N-stage was verified by mediastinoscopy. Afterward, consensus reading was performed.In 52 patients, surgery served as gold standard. In 2 patients, follow-up control served as gold standard as an inoperable situation with distant metastases was found. Additionally, interobserver variability (kappa value) was calculated. RESULTS: In stage II, accuracy was 0.77 (CT), 0.86 (PET), 0.8 (MRI), 1.0 (PET/CT), and in stage III 0.75, 0.83, 0.9, 1.0. PET/CT was significantly more accurate (P < 0.05) in stages II and III compared with all other techniques. CT and MRI were not able to detect distant metastases in 2 patients, which changed therapy (operable vs. inoperable). Interobserver variability was 0.7, 0.9, 0.8, 1.0 in stage II and 0.9, 0.9, 0.9, 1.0 in stage III. CONCLUSION: PET/CT makes it possible to stage patients with limited MPM with high accuracy and low interobserver variability. |
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Authors:
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Christian Plathow; Adrian Staab; Astrid Schmaehl; Philip Aschoff; Ivan Zuna; Christina Pfannenberg; Schlemmer Heinz Peter; Susanne Eschmann; Michael Klopp |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article |
Journal Detail:
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Title: Investigative radiology Volume: 43 ISSN: 1536-0210 ISO Abbreviation: Invest Radiol Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-15 Completed Date: 2009-01-07 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 737-44 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Radiology, University of Tuebingen, Tuebingen, Germany. christian.plathow@uniklinik-freiburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Female Humans Karnofsky Performance Status Magnetic Resonance Imaging / instrumentation* Male Mesothelioma / diagnosis*, physiopathology Middle Aged Neoplasm Staging / instrumentation, methods Positron-Emission Tomography / instrumentation* Tomography, X-Ray Computed / instrumentation |
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