| Computed tomography monitoring of radiation-induced lung fibrosis in mice. | |
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MedLine Citation:
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PMID: 15377939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE AND OBJECTIVES: To identify characteristics of lung fibrosis in a mouse model after radiotherapy (RT) using thin-section computed tomography (CT), histology and clinical parameters. MATERIALS AND METHOD: Using a multislice CT-scanner, follow-up chest CT scans of 10 out of 72 included mice (C57BL/6J, 36 control mice, 36 mice (20Gy)) were performed every 2 weeks until week 26 after RT. Hounsfield units (HU) and cardiothoracic ratio (CTR) were measured, and a multireader analysis on characteristic lung changes was performed and correlated with histology and clinical parameters. RESULTS: From weeks 4 to 8 after RT changes in histology (leukocyte count, extraalveolar edema, P < 0.01) and from week 12 changes in CT were detected (increase in HU, intralobular opacity and fibrotic strandings, P < 0.05). From week 14 clinical manifestations occurred (loss of weight, mobility, breathing, increased mortality, P < 0.01). CTR showed no significant changes. Three readers showed excellent interobserver agreement (kappa >0.84). CONCLUSION: Thin-section CT in a mouse model is capable of detecting the development of lung fibrosis after RT prior to the onset of clinical deterioration. |
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Authors:
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Christian Plathow; Minglun Li; Ping Gong; Heike Zieher; Fabian Kiessling; Peter Peschke; Hans-Ulrich Kauczor; Amir Abdollahi; Peter E Huber |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Investigative radiology Volume: 39 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-09-20 Completed Date: 2005-02-08 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 600-9 Citation Subset: IM |
Affiliation:
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Department of Radiology, Deutsches Krebsforschungszentrum Heidelberg, Germany. c.plathow@dkfz.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Edema Female Histological Techniques Leukocyte Count Mice Mice, Inbred C57BL Models, Animal Monitoring, Physiologic Pulmonary Fibrosis / physiopathology*, radiography* Radiation Injuries, Experimental / physiopathology* Thorax / radiation effects Tomography, X-Ray Computed* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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