Document Detail

Computed tomography in Alzheimer's disease: a longitudinal study.
MedLine Citation:
PMID:  2036479     Owner:  NLM     Status:  MEDLINE    
Sixty-three patients satisfying NINCDS/ADRDA criteria for Alzheimer's disease (AD) received neuropsychological tests and computed tomography (CT) scans 12 months apart. Significant deterioration occurred in all the cognitive tests and in the CT measures used, that is, lateral ventricular size, third ventricular size, and cortical atrophy. There was a wide variation in the size of the changes taking place; 14 of 63 patients showed no significant change and 6 showed a marked increase in ventricular size. However, neither group differed from the others in any demographic, cognitive, or other CT variables which suggested, on the CT measures used, that no clearly identifiable subgroups of AD were present. Change in CT indices was not related to initial severity of disease. An increase in ventricular size was related to deterioration of cognitive function. These results require further replication. The methodological drawbacks of such studies are discussed.
A Burns; R Jacoby; R Levy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological psychiatry     Volume:  29     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-07-03     Completed Date:  1991-07-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  383-90     Citation Subset:  IM    
Section of Old Age Psychiatry, Institute of Psychiatry, London, England.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / psychology,  radiography*
Basal Ganglia / radiography
Calcinosis / radiography
Cerebral Infarction / radiography
Cerebral Ventriculography
Follow-Up Studies
Longitudinal Studies
Neuropsychological Tests
Tomography, X-Ray Computed*

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