Document Detail

Computed tomography-based diagnosis of diffuse compensatory enlargement of coronary arteries using scaling power laws.
MedLine Citation:
PMID:  23365197     Owner:  NLM     Status:  MEDLINE    
Glagov's positive remodelling in the early stages of coronary atherosclerosis often results in plaque rupture and acute events. Because positive remodelling is generally diffused along the epicardial coronary arterial tree, it is difficult to diagnose non-invasively. Hence, the objective of the study is to assess the use of scaling power law for the diagnosis of positive remodelling of coronary arteries based on computed tomography (CT) images. Epicardial coronary arterial trees were reconstructed from CT scans of six Ossabaw pigs fed on a high-fat, high-cholesterol, atherogenic diet for eight months as well as the same number of body-weight-matched farm pigs fed on a lean chow (101.9±16.1 versus 91.5±13.1 kg). The high-fat diet Ossabaw pig model showed diffuse positive remodelling of epicardial coronary arteries. Good fit of measured coronary data to the length-volume scaling power law ( where L(c) and V(c) are crown length and volume) were found for both the high-fat and control groups (R(2) = 0.95±0.04 and 0.99±0.01, respectively). The coefficient, K(LV), decreased significantly in the high-fat diet group when compared with the control (14.6±2.6 versus 40.9±5.6). The flow-length scaling power law, however, was nearly unaffected by the positive remodelling. The length-volume and flow-length scaling power laws were preserved in epicardial coronary arterial trees after positive remodelling. K(LV) < 18 in the length-volume scaling relation is a good index of positive remodelling of coronary arteries. These findings provide a clinical rationale for simple, accurate and non-invasive diagnosis of positive remodelling of coronary arteries, using conventional CT scans.
Yunlong Huo; Jenny Susana Choy; Thomas Wischgoll; Tong Luo; Shawn D Teague; Deepak L Bhatt; Ghassan S Kassab
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-30
Journal Detail:
Title:  Journal of the Royal Society, Interface / the Royal Society     Volume:  10     ISSN:  1742-5662     ISO Abbreviation:  J R Soc Interface     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-01-31     Completed Date:  2013-07-05     Revised Date:  2014-04-10    
Medline Journal Info:
Nlm Unique ID:  101217269     Medline TA:  J R Soc Interface     Country:  England    
Other Details:
Languages:  eng     Pagination:  20121015     Citation Subset:  IM    
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MeSH Terms
Blood Flow Velocity / physiology
Coronary Artery Disease / diagnosis*,  pathology*
Coronary Vessels / physiopathology*,  radiography
Diet, Atherogenic
Least-Squares Analysis
Models, Biological
Sus scrofa
Tomography, X-Ray Computed / methods*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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