| Computed Tomography Perfusion Imaging for Therapeutic Assessment: Has It Come of Age as a Biomarker in Oncology? | |
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MedLine Citation:
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PMID: 21808202 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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With the emergence of novel targeted therapies, imaging techniques that assess tumor vascular support have gained credence for response assessment alongside standard response criteria. Computed tomography (CT) perfusion techniques that quantify regional tumor blood flow, blood volume, flow-extraction product, and permeability-surface area product through standard kinetic models are attractive, but the level of evidence for CT perfusion to be a truly mature biomarker remains insufficient. Studies to date have not been powered to assess this. Future studies that include good quality prospective validation correlating perfusion CT to outcome end points in the trial setting are needed to take CT perfusion forward as a biomarker in oncology. |
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Authors:
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Vicky Goh; Quan Sing Ng; Ken Miles |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-29 |
Journal Detail:
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Title: Investigative radiology Volume: - ISSN: 1536-0210 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-8-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the *Division of Imaging Sciences, School of Medicine, King's College London, London, United Kingdom; †Department of Medical Oncology, National Cancer Centre, Singapore; and ‡Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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