| Computational simulations for aortic coarctation: representative results from a sampling of patients. | |
| | |
MedLine Citation:
|
PMID: 22010743 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Treatments for coarctation of the aorta (CoA) can alleviate blood pressure (BP) gradients (Δ), but long-term morbidity still exists that can be explained by altered indices of hemodynamics and biomechanics. We introduce a technique to increase our understanding of these indices for CoA under resting and nonresting conditions, quantify their contribution to morbidity, and evaluate treatment options. Patient-specific computational fluid dynamics (CFD) models were created from imaging and BP data for one normal and four CoA patients (moderate native CoA: Δ12 mmHg, severe native CoA: Δ25 mmHg and postoperative end-to-end and end-to-side patients: Δ0 mmHg). Simulations incorporated vessel deformation, downstream vascular resistance and compliance. Indices including cyclic strain, time-averaged wall shear stress (TAWSS), and oscillatory shear index (OSI) were quantified. Simulations replicated resting BP and blood flow data. BP during simulated exercise for the normal patient matched reported values. Greatest exercise-induced increases in systolic BP and mean and peak ΔBP occurred for the moderate native CoA patient (SBP: 115 to 154 mmHg; mean and peak ΔBP: 31 and 73 mmHg). Cyclic strain was elevated proximal to the coarctation for native CoA patients, but reduced throughout the aorta after treatment. A greater percentage of vessels was exposed to subnormal TAWSS or elevated OSI for CoA patients. Local patterns of these indices reported to correlate with atherosclerosis in normal patients were accentuated by CoA. These results apply CFD to a range of CoA patients for the first time and provide the foundation for future progress in this area. |
| | |
Authors:
|
John F Ladisa; C Alberto Figueroa; Irene E Vignon-Clementel; Hyun Jin Kim; Nan Xiao; Laura M Ellwein; Frandics P Chan; Jeffrey A Feinstein; Charles A Taylor |
Related Documents
:
|
3252213 - Use of the 'h' reflex recovery curve in selective posterior rhizotomy. 2242173 - Recurrent lateral rectus palsy in childhood. 18385913 - Comparison of tiotropium bromide and combined ipratropium/salbutamol for the treatment ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of biomechanical engineering Volume: 133 ISSN: 1528-8951 ISO Abbreviation: J Biomech Eng Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-10-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7909584 Medline TA: J Biomech Eng Country: United States |
Other Details:
|
Languages: eng Pagination: 091008 Citation Subset: IM |
Affiliation:
|
Department of Biomedical Engineering, Marquette University, Milwaukee, WI 53233; Department of Pediatrics, Children's Hospital of Wisconsin, Milwaukee, WI 53226 e-mail: john.ladisa@mu.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A nonlinear model of passive muscle viscosity.
Next Document: Dynamic response of intraocular pressure and biomechanical effects of the eye considering fluid-stru...