| Computational simulation of the blood separation process. | |
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MedLine Citation:
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PMID: 16048484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this work is to construct a computational fluid dynamics model capable of simulating the quasitransient process of apheresis. To this end a Lagrangian-Eulerian model has been developed which tracks the blood particles within a delineated two-dimensional flow domain. Within the Eulerian method, the fluid flow conservation equations within the separator are solved. Taking the calculated values of the flow field and using a Lagrangian method, the displacement of the blood particles is calculated. Thus, the local blood density within the separator at a given time step is known. Subsequently, the flow field in the separator is recalculated. This process continues until a quasisteady behavior is reached. The simulations show good agreement with experimental results. They shows a complete separation of plasma and red blood cells, as well as nearly complete separation of red blood cells and platelets. The white blood cells build clusters in the low concentrate cell bed. |
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Authors:
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Sandro De Gruttola; Kevin Boomsma; Dimos Poulikakos; Yiannis Ventikos |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Artificial organs Volume: 29 ISSN: 0160-564X ISO Abbreviation: Artif Organs Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-07-28 Completed Date: 2005-12-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: United States |
Other Details:
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Languages: eng Pagination: 665-74 Citation Subset: IM |
Affiliation:
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Laboratory of Thermodynamics in Emerging Technologies, Department of Mechanical and Process Engineering, Swiss Federal Institute of Technology, Zurich, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Cells Blood Component Removal / methods* Computer Simulation Hemorheology / methods* Models, Cardiovascular |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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