Document Detail


Computational patient-specific models based on 3-D ultrasound data to quantify uterine arterial flow during pregnancy.
MedLine Citation:
PMID:  19033087     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Information on uterine blood flow rate during pregnancy would widely improve our knowledge on feto-placental patho-physiology. Ultrasonographic flow rate evaluation requires the knowledge of the spatial velocity profiles throughout the investigated vessel; these data may be obtained from hemodynamic simulations with accurate computational models. Recently, computational models of superficial vessels have been created using 3-D ultrasound data; unfortunately, common reconstruction methods are unsuitable for the uterine arteries due to the low quality achievable of imaged deep vessels. In this paper a simplified spline-based technique was applied to create computational models for patient-specific simulations of uterine arterial heamodynamics. Moreover, a novel method to quantify the uterine flow rates was developed based on echo-Doppler measurements and computational data. Preliminary results obtained for four patients indicated a quite narrow range for the blood flow rate through the main uterine artery with large variability in the flow split between corporal and cervical branches. Furthermore, parabolic-like velocity profiles were obtained in the branching region of the different patients, suggesting a clinical use of averaged, not patient-specific, spatial velocity distribution coefficients for the blood flow rate calculation. The developed reconstruction method based on 3-D ultrasound imaging is efficient for creating realistic custom models of the uterine arteries. The results of the fluid dynamic simulations allowed us to quantify the uterine arterial flow and its repartition in normal pregnancies.
Authors:
Giancarlo Pennati; Laura Socci; Serena Rigano; Simona Boito; Enrico Ferrazzi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  IEEE transactions on medical imaging     Volume:  27     ISSN:  1558-254X     ISO Abbreviation:  IEEE Trans Med Imaging     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-26     Completed Date:  2009-05-19     Revised Date:  2012-04-24    
Medline Journal Info:
Nlm Unique ID:  8310780     Medline TA:  IEEE Trans Med Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1715-22     Citation Subset:  IM    
Affiliation:
Laboratory of Biological Structures, Department of Structural Engineering, Politecnico di Milano, 20133 Milan, Italy. giancarlo.pennati@polimi.it
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Blood Flow Velocity / physiology
Blood Vessels / ultrasonography
Female
Humans
Image Interpretation, Computer-Assisted / methods
Imaging, Three-Dimensional / methods*
Models, Cardiovascular
Pregnancy
Pulsatile Flow / physiology
Ultrasonography, Doppler, Color / methods*
Uterus / blood supply*,  ultrasonography*
Grant Support
ID/Acronym/Agency:
5 RO1 HD034837-8/HD/NICHD NIH HHS; M01 RR000069/RR/NCRR NIH HHS

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