Document Detail

Computational modeling of GABAA receptor-mediated paired-pulse inhibition in the dentate gyrus.
MedLine Citation:
PMID:  20177763     Owner:  NLM     Status:  In-Process    
Paired-pulse inhibition (PPI) of the population spike observed in extracellular field recordings is widely used as a read-out of hippocampal network inhibition. PPI reflects GABA(A) receptor-mediated inhibition of principal neurons through local interneurons. However, because of its polysynaptic nature, it is difficult to assign PPI changes to precise synaptic mechanisms. Here we used a detailed network model of the dentate gyrus to simulate PPI of granule cell action potentials and analyze its network properties. Our computational analysis indicates that PPI results mainly from a combination of perisomatic feed-forward and feedback inhibition of granule cells by basket cells. Feed-forward inhibition mediated by basket cells appeared to be the most significant source of PPI. Our simulations suggest that PPI depends more on somatic than on dendritic inhibition of granule cells. Furthermore, PPI was modulated by changes in GABA(A) reversal potential (E(GABA)) and by alterations in intrinsic excitability of granule cells. In summary, computer modeling provides a useful tool for determining the role of synaptic and intrinsic cellular mechanisms in paired-pulse field potential responses.
Peter Jedlicka; Thomas Deller; Stephan W Schwarzacher
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-23
Journal Detail:
Title:  Journal of computational neuroscience     Volume:  29     ISSN:  1573-6873     ISO Abbreviation:  J Comput Neurosci     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9439510     Medline TA:  J Comput Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  509-19     Citation Subset:  IM    
Institute of Clinical Neuroanatomy, Goethe-University, NeuroScience Center, 60590, Frankfurt am Main, Germany.
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