Document Detail

Computational model for simulation of vascular adaptation following vascular access surgery in haemodialysis patients.
MedLine Citation:
PMID:  23281788     Owner:  NLM     Status:  Publisher    
An important number of surgical procedures for creation of vascular access (VA) in haemodialysis patients still results in non-adequate increase in blood flow (non-maturation). The rise in blood flow in arteriovenous shunts depends on vascular remodelling. Computational tools to predict the outcome of VA surgery would be important in this clinical context. The aim of our investigation was then to develop a 0D/1D computational model of arm vasculature able to simulate vessel wall remodelling and related changes in blood flow. We assumed that blood vessel remodelling is driven by peak wall shear stress. The model was calibrated with previously reported values of radial artery diameter and blood flow after end-to-end distal fistula creation. Good agreement was obtained between predicted changes in VA flow and in arterial diameter after surgery and corresponding measured values. The use of this computational model may allow accurate vascular surgery planning and ameliorate VA surgery outcomes.
Simone Manini; Katia Passera; Wouter Huberts; Lorenzo Botti; Luca Antiga; Andrea Remuzzi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-3
Journal Detail:
Title:  Computer methods in biomechanics and biomedical engineering     Volume:  -     ISSN:  1476-8259     ISO Abbreviation:  Comput Methods Biomech Biomed Engin     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9802899     Medline TA:  Comput Methods Biomech Biomed Engin     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a Department of Biomedical Engineering , Mario Negri Institute for Pharmacological Research , Bergamo , Italy.
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