| Computational model of glucose homeostasis during exercise. | |
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MedLine Citation:
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PMID: 17946814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A mathematical model of whole-body metabolism is developed to predict glucose homeostasis during exercise by using a hormonal controller over cellular metabolic processes. Model simulations were validated with experimental data from exercise studies in humans. The exercise-induced changes in hormonal signals modulated metabolic flux rates of various tissues in a coordinated way to maintain blood glucose constant. This study demonstrates the efficacy of a multi-tissue controller to accomplish blood glucose homeostasis by integrating the outputs of tissues under hormonal control. In conclusion, this model can be used as a valuable complement to experimental studies due to its ability to predict what is difficult to measure directly and to provide dynamic information about the system. |
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Authors:
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Jaeyeon Kim; Gerald M Saidel; John P Kirwan; Marco E Cabrera |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference Volume: 1 ISSN: 1557-170X ISO Abbreviation: Conf Proc IEEE Eng Med Biol Soc Publication Date: 2006 |
Date Detail:
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Created Date: 2007-10-23 Completed Date: 2008-03-06 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101243413 Medline TA: Conf Proc IEEE Eng Med Biol Soc Country: United States |
Other Details:
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Languages: eng Pagination: 311-4 Citation Subset: IM |
Affiliation:
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Case Western Reserve University, Cleveland, OH 44106, USA. jyk6@case.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Computer Simulation Exercise / physiology* Exercise Test Glucose / metabolism* Homeostasis / physiology* Humans Insulin / metabolism* Metabolic Clearance Rate Models, Biological* Organ Specificity / physiology* Physical Exertion / physiology* Tissue Distribution |
| Grant Support | |
ID/Acronym/Agency:
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P50-GM-66309/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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