Document Detail


Computational model of glucose homeostasis during exercise.
MedLine Citation:
PMID:  17946814     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A mathematical model of whole-body metabolism is developed to predict glucose homeostasis during exercise by using a hormonal controller over cellular metabolic processes. Model simulations were validated with experimental data from exercise studies in humans. The exercise-induced changes in hormonal signals modulated metabolic flux rates of various tissues in a coordinated way to maintain blood glucose constant. This study demonstrates the efficacy of a multi-tissue controller to accomplish blood glucose homeostasis by integrating the outputs of tissues under hormonal control. In conclusion, this model can be used as a valuable complement to experimental studies due to its ability to predict what is difficult to measure directly and to provide dynamic information about the system.
Authors:
Jaeyeon Kim; Gerald M Saidel; John P Kirwan; Marco E Cabrera
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  1     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2006  
Date Detail:
Created Date:  2007-10-23     Completed Date:  2008-03-06     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  311-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Computer Simulation
Exercise / physiology*
Exercise Test
Glucose / metabolism*
Homeostasis / physiology*
Humans
Insulin / metabolism*
Metabolic Clearance Rate
Models, Biological*
Organ Specificity / physiology*
Physical Exertion / physiology*
Tissue Distribution
Grant Support
ID/Acronym/Agency:
P50-GM-66309/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Insulin; IY9XDZ35W2/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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