Document Detail


Computational model for the cell-mechanical response of the osteocyte cytoskeleton based on self-stabilizing tensegrity structures.
MedLine Citation:
PMID:  22527364     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The mechanism by which mechanical stimulation on osteocytes results in biochemical signals that initiate the remodeling process inside living bone tissue is largely unknown. Even the type of stimulation acting on these cells is not yet clearly identified. However, the cytoskeleton of osteocytes is suggested to play a major role in the mechanosensory process due to the direct connection to the nucleus. In this paper, a computational approach to model and simulate the cell structure of osteocytes based on self-stabilizing tensegrity structures is suggested. The computational model of the cell consists of the major components with respect to mechanical aspects: the integrins that connect the cell with the extracellular bone matrix, and different types of protein fibers (microtubules and intermediate filaments) that form the cytoskeleton, the membrane-cytoskeleton (microfilaments), the nucleus and the centrosome. The proposed geometrical cell models represent the cell in its physiological environment which is necessary in order to give a statement on the cell behavior in vivo. Studies on the mechanical response of osteocytes after physiological loading and in particular the mechanical response of the nucleus show that the load acting on the nucleus is rising with increasing deformation applied to the integrins.
Authors:
Dieter Kardas; Udo Nackenhorst; Daniel Balzani
Related Documents :
21706474 - Oct2, ssx and sage1 reveal the phenotypic heterogeneity of spermatocytic seminoma refle...
6403224 - Cell cycle age response of 9l cells to 1,3-bis(2-chloroethyl)-1-nitrosourea and modific...
628934 - Estimation of cell cycle parameters by the cumulative method.
10458784 - Spontaneous enantiomeric resolution in a fluid smectic phase of a racemate.
17635654 - Centrifugation of bacterial cells on slide surface improves the spatial distribution, c...
6609784 - The effect of diethylstilboestrol on the in vitro growth of human ectocervical cells.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-21
Journal Detail:
Title:  Biomechanics and modeling in mechanobiology     Volume:  -     ISSN:  1617-7940     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135325     Medline TA:  Biomech Model Mechanobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institute of Mechanics and Computational Mechanics, Leibniz Universität Hannover, Hanover, Germany, kardas@ibnm.uni-hannover.de.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Analytical and numerical analyses of the micromechanics of soft fibrous connective tissues.
Next Document:  An anisotropic elastic-viscoplastic damage model for bone tissue.