Document Detail


Computational model of atrial electrical activation and propagation.
MedLine Citation:
PMID:  18002104     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have developed a finite-element surface model of human atria, in order to study normal and abnormal patterns of atrial activation. To characterize electrical activity in both atrial muscle and cardiac pacemaker regions, Fitzhugh-Nagumo-type equations were employed. Model equations were tested using a simplified geometry containing major topological features of both atria. The model is able to generate spontaneous activation of electrical impulses within the sinoatrial node which propagate across the atria. The model can be used as a basis for investigating mechanisms underlying normal and abnormal atrial rhythms, including re-entrant activation by an ectopic focus.
Authors:
Socrates Dokos; Shaun L Cloherty; Nigel H Lovell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference     Volume:  2007     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-03-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  908-11     Citation Subset:  IM    
Affiliation:
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, 2052, Australia. s.dokos@unsw.edu.au
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology*
Atrial Function / physiology*
Biological Clocks / physiology*
Computer Simulation
Heart Conduction System / physiology*
Humans
Models, Cardiovascular*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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