| Computational methods in molecular diversity and combinatorial chemistry. | |
| | |
MedLine Citation:
|
PMID: 9691077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Molecular diversity, combinatorial chemistry and automated synthesis are helping usher in a new age in medicinal chemistry. The tools and practices of computational chemistry and molecular modeling are rising to the challenges and opportunities presented by the current trends in drug discovery and design. Recent advances include a number of new and meaningful measures of molecular diversity and the use of genetic algorithms to help design diverse libraries. |
| | |
Authors:
|
M G Bures; Y C Martin |
Related Documents
:
|
15657477 - Protein nanotechnology: the new frontier in biosciences. 19929827 - Qm/mm approaches in medicinal chemistry research. 8759627 - Bioisosterism as a molecular diversity descriptor: steric fields of single "topomeric" ... 19944787 - Underrepresentation of underrepresented minorities in academic medicine: the need to en... 10114917 - Middle managers: gatekeepers for turnover. 20164777 - Prehospital ultrasound in emergency medicine: incidence, feasibility, indications and d... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Current opinion in chemical biology Volume: 2 ISSN: 1367-5931 ISO Abbreviation: Curr Opin Chem Biol Publication Date: 1998 Jun |
Date Detail:
|
Created Date: 1998-10-30 Completed Date: 1998-10-30 Revised Date: 2009-08-25 |
Medline Journal Info:
|
Nlm Unique ID: 9811312 Medline TA: Curr Opin Chem Biol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 376-80 Citation Subset: IM |
Affiliation:
|
Abbott Laboratories, Abbott Park, IL 60064-3500, USA. mark.bures@abbott.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Algorithms Chemistry, Organic / methods* Drug Design Models, Molecular Molecular Structure Reproducibility of Results Software |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Combinatorial libraries of transition-metal complexes, catalysts and materials.
Next Document: Analysing genetic information with DNA arrays.