Document Detail


Computational fluid dynamics simulations of intracranial aneurysms at varying heart rates: a "patient-specific" study.
MedLine Citation:
PMID:  19725690     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rupture of an intracranial aneurysm (IA) is frequently associated with intense physical exertion and/or emotional excitement, events that are typically also accompanied by sudden significant changes in both heart rate and blood pressure. Very few experimental studies of aneurysm hemodynamics have examined the impact on hemodynamic parameters in and around an aneurysm resulting from changes in heart rate. In order to further understanding these changes, as they relate to hemodynamic features that may contribute to rupture of an IA, we examined the characteristics of pulsatile flow in and around two "patient-specific" intracranial aneurysms at three different cardiac frequencies. Three dimensional X-ray angiographic data (3D-DSA) were used to reconstruct accurate and patient-specific aneurysm geometries. Then, computational fluid dynamics techniques were utilized to analyze the characteristics of blood flow in and around the two aneurysms. Physiologically realistic flow conditions, as measured by transcranial Doppler ultrasound, were used in the simulations. Our results showed that there were significant changes in the overall flow patterns (e.g., vortex formation and translation) associated with the changes of heart rates. In both aneurysms, the calculated wall shear stress exhibited substantial increases with an increase in heart rate. Our results suggest that the changes in local hemodynamic forces associated with variations in heart rate are dependent not only on the heart rate but also on the aneurysm geometry. This thus precludes applying our observations about the impact of variations in cardiac rate to aneurysms in general.
Authors:
Jingfeng Jiang; Charles Strother
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomechanical engineering     Volume:  131     ISSN:  1528-8951     ISO Abbreviation:  J Biomech Eng     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-03     Completed Date:  2009-12-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909584     Medline TA:  J Biomech Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  091001     Citation Subset:  IM    
Affiliation:
Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA. jjiang2@wisc.edu
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MeSH Terms
Descriptor/Qualifier:
Blood Flow Velocity*
Computer Simulation
Heart Rate*
Humans
Intracranial Aneurysm / physiopathology*
Models, Cardiovascular*
Pulsatile Flow*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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