| Computational fluid dynamics of aggregating red blood cells in postcapillary venules. | |
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MedLine Citation:
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PMID: 19675976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aggregate formation of red blood cells (RBCs) in a postcapillary venular bifurcation is investigated with three-dimensional computer simulations using the Chimera grid method. Interaction energy between the RBCs is modelled by a depletion interaction theory; RBCs are modelled as rigid oblate ellipsoids. The cell-cell interactions of RBCs are strongly dependent on vessel geometry and shear rates. The experimental data on vessel geometry, pseudoshear rates, and Dextran concentration obtained in our previous in vivo RBC aggregation study in postcapillary venules of the rat spinotrapezius muscle were used to simulate RBC aggregation. The computational results were compared to the experimental results from the in vivo study. The results show that cells have a larger tendency to form an aggregate under reduced flows. Aggregate formation also depends on the angle and location of the cells before they enter the bifurcation region. Comparisons with experimental data are discussed. |
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Authors:
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Bong Chung; Sangho Kim; Paul C Johnson; Aleksander S Popel |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Computer methods in biomechanics and biomedical engineering Volume: 12 ISSN: 1476-8259 ISO Abbreviation: Comput Methods Biomech Biomed Engin Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-13 Completed Date: 2009-11-16 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9802899 Medline TA: Comput Methods Biomech Biomed Engin Country: England |
Other Details:
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Languages: eng Pagination: 385-97 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, USA. bchung6@jhu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomedical Engineering Blood Flow Velocity Cell Aggregation / physiology* Computer Simulation* Erythrocytes / cytology, physiology* Imaging, Three-Dimensional Models, Cardiovascular* Rats Venules / anatomy & histology*, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL18292/HL/NHLBI NIH HHS; R01 HL018292-31/HL/NHLBI NIH HHS; R01 HL052684-09/HL/NHLBI NIH HHS; R01 HL52684/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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