| Computational design and experimental performance testing of an axial-flow pediatric ventricular assist device. | |
| | |
MedLine Citation:
|
PMID: 16322729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The Virginia Artificial Heart Institute continues to design and develop an axial-flow pediatric ventricular assist device (PVAD) for infants and children in the United States. Our research team has created a database to track potential PVAD candidates at the University of Virginia Children's Hospital. The findings of this database aided with need assessment and design optimization of the PVAD. A numerical analysis of the optimized PVAD1 design (PVAD2 model) was also completed using computational fluid dynamics (CFD) to predict pressure-flow performance, fluid force estimations, and blood damage levels in the flow domain. Based on the PVAD2 model and after alterations to accommodate manufacturing, a plastic prototype for experimental flow testing was constructed via rapid prototyping techniques or stereolithography. CFD predictions demonstrated a pressure rise range of 36-118 mm Hg and axial fluid forces of 0.8-1.7 N for flows of 0.5-3 l/min over 7000-9000 rpm. Blood damage indices per CFD ranged from 0.24% to 0.35% for 200 massless and inert particles analyzed. Approximately 187 (93.5%) of the particles took less than 0.14 seconds to travel completely through the PVAD. The mean residence time was 0.105 seconds with a maximum time of 0.224 seconds. Additionally, in a water/glycerin blood analog solution, the plastic prototype produced pressure rises of 20-160 mm Hg for rotational speeds of 5960 +/- 18 rpm to 9975 +/- 31 rpm over flows from 0.5 to 4.5 l/min. The numerical results for the PVAD2 and the prototype hydraulic testing indicate an acceptable design for the pump, represent a significant step in the development phase of this device, and encourage manufacturing of a magnetically levitated prototype for animal experiments. |
| | |
Authors:
|
Amy L Throckmorton; D Scott Lim; Michael A McCulloch; Wei Jiang; Xinwei Song; Paul E Allaire; Houston G Wood; Don B Olsen |
Related Documents
:
|
10176129 - The design and application of a pediatric centrifugal pump. 12117759 - Physics and applications of microfluidics in biology. 3705149 - Evaluation of a volumetric intravenous fluid infusion pump for transfusion of blood com... 17445759 - Multiphase flow in microfluidic systems --control and applications of droplets and inte... 16615689 - Systemic arterial waveform analysis and assessment of blood flow during extracorporeal ... 6702849 - Effects of intravenous delivery systems on infused red blood cells. 15247999 - Intraoperative transcranial ultrasonic monitoring for cardiac and vascular surgery. 7880489 - Congener production in blood samples during preparation and storage. 22606689 - Simplified sheath flow cuvette design for ultrasensitive laser induced fluorescence det... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 51 ISSN: 1058-2916 ISO Abbreviation: ASAIO J. Publication Date: 2005 Sep-Oct |
Date Detail:
|
Created Date: 2005-12-08 Completed Date: 2006-02-06 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
|
Languages: eng Pagination: 629-35 Citation Subset: IM |
Affiliation:
|
Department of Biomedical Engineering, Virginia Artificial Heart Institute, University of Virginia, Charlottesville, VA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Blood Circulation Blood Pressure Body Surface Area Child Child, Preschool Computational Biology* Computer Simulation Databases, Factual Equipment Design* Female Heart Transplantation Heart-Assist Devices* Hematocrit Hemodynamics Hemorheology Humans Infant Infant, Newborn Magnetics Male Numerical Analysis, Computer-Assisted Rotation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Coupling pediatric ventricle assist devices to the Fontan circulation: simulations with a lumped-par...
Next Document: Elimination of adverse leakage flow in a miniature pediatric centrifugal blood pump by computational...