Document Detail

Computational design and experimental performance testing of an axial-flow pediatric ventricular assist device.
MedLine Citation:
PMID:  16322729     Owner:  NLM     Status:  MEDLINE    
The Virginia Artificial Heart Institute continues to design and develop an axial-flow pediatric ventricular assist device (PVAD) for infants and children in the United States. Our research team has created a database to track potential PVAD candidates at the University of Virginia Children's Hospital. The findings of this database aided with need assessment and design optimization of the PVAD. A numerical analysis of the optimized PVAD1 design (PVAD2 model) was also completed using computational fluid dynamics (CFD) to predict pressure-flow performance, fluid force estimations, and blood damage levels in the flow domain. Based on the PVAD2 model and after alterations to accommodate manufacturing, a plastic prototype for experimental flow testing was constructed via rapid prototyping techniques or stereolithography. CFD predictions demonstrated a pressure rise range of 36-118 mm Hg and axial fluid forces of 0.8-1.7 N for flows of 0.5-3 l/min over 7000-9000 rpm. Blood damage indices per CFD ranged from 0.24% to 0.35% for 200 massless and inert particles analyzed. Approximately 187 (93.5%) of the particles took less than 0.14 seconds to travel completely through the PVAD. The mean residence time was 0.105 seconds with a maximum time of 0.224 seconds. Additionally, in a water/glycerin blood analog solution, the plastic prototype produced pressure rises of 20-160 mm Hg for rotational speeds of 5960 +/- 18 rpm to 9975 +/- 31 rpm over flows from 0.5 to 4.5 l/min. The numerical results for the PVAD2 and the prototype hydraulic testing indicate an acceptable design for the pump, represent a significant step in the development phase of this device, and encourage manufacturing of a magnetically levitated prototype for animal experiments.
Amy L Throckmorton; D Scott Lim; Michael A McCulloch; Wei Jiang; Xinwei Song; Paul E Allaire; Houston G Wood; Don B Olsen
Related Documents :
8222539 - Volume blood flow measurements with a transit time flowmeter: an in vivo and in vitro v...
10174299 - Incidence of electrocardiographic changes during cytapheresis using an intermittent flo...
10417459 - An in vitro evaluation of flow from multihole epidural catheters during continuous infu...
9271179 - Development of a non-pulsatile permanent rotary blood pump.
2339159 - Is the polar bear (ursus maritimus) a hibernator? continued studies on opioids and hibe...
16409399 - Continuous venovenous renal replacement therapy with a pulsatile tubular blood pump: an...
14644649 - Validation of a minimally invasive blood-sampling technique for the analysis of hormone...
8839509 - Gastric acidity influences the blood response to a beta-carotene dose in humans.
9179119 - Open heart operations without transfusion using a multimodality blood conservation stra...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  51     ISSN:  1058-2916     ISO Abbreviation:  ASAIO J.     Publication Date:    2005 Sep-Oct
Date Detail:
Created Date:  2005-12-08     Completed Date:  2006-02-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  629-35     Citation Subset:  IM    
Department of Biomedical Engineering, Virginia Artificial Heart Institute, University of Virginia, Charlottesville, VA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Circulation
Blood Pressure
Body Surface Area
Child, Preschool
Computational Biology*
Computer Simulation
Databases, Factual
Equipment Design*
Heart Transplantation
Heart-Assist Devices*
Infant, Newborn
Numerical Analysis, Computer-Assisted

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Coupling pediatric ventricle assist devices to the Fontan circulation: simulations with a lumped-par...
Next Document:  Elimination of adverse leakage flow in a miniature pediatric centrifugal blood pump by computational...