Document Detail


Computational analysis and identification of an emergent human adenovirus pathogen implicated in a respiratory fatality.
MedLine Citation:
PMID:  21056888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adenoviral infections are typically acute, self-limiting, and not associated with death. However, we present the genomic and bioinformatics analysis of a novel recombinant human adenovirus (HAdV-D56) isolated in France that caused a rare neonatal fatality, and keratoconjunctivitis in three health care workers who cared for the neonate. Whole genome alignments revealed the expected diversity in the penton base, hexon, E3, and fiber coding regions, and provided evidence for extensive recombination. Bootscan analysis confirmed recombination between HAdV-D9, HAdV-D26, HAdV-D15, and HAdV-D29 in the penton base and hexon proteins, centered around hypervariable loops within the putative proteins. Protein structure analysis of the fiber coding region revealed similarity with HAdV-D8, HAdV-D9, and HAdV-D53, possibly accounting for the ocular tropism of the virus. Based on these data, this virus appears to be a new HAdV-D type (HAdV-D56), underscoring the importance of recombination events in human adenovirus evolution and the emergence of new adenovirus pathogens.
Authors:
Christopher M Robinson; Gurdeep Singh; Cécile Henquell; Michael P Walsh; Hélène Peigue-Lafeuille; Donald Seto; Morris S Jones; David W Dyer; James Chodosh
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-11-05
Journal Detail:
Title:  Virology     Volume:  409     ISSN:  1096-0341     ISO Abbreviation:  Virology     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-21     Completed Date:  2011-01-18     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0110674     Medline TA:  Virology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  141-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/HM770721
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MeSH Terms
Descriptor/Qualifier:
Adenoviruses, Human / genetics*,  isolation & purification*,  pathogenicity
Amino Acid Sequence
Cluster Analysis
Computational Biology
DNA, Viral / chemistry,  genetics
Evolution, Molecular
Fatal Outcome
France
Genome, Viral
Humans
Infant, Newborn
Keratoconjunctivitis / virology
Molecular Sequence Data
Phylogeny
Recombination, Genetic
Respiratory Tract Infections / mortality,  transmission*,  virology*
Sequence Alignment
Sequence Analysis, DNA
Viral Proteins / genetics
Grant Support
ID/Acronym/Agency:
EY013124-S1/EY/NEI NIH HHS; P30EY014104/EY/NEI NIH HHS; R01 EY013124/EY/NEI NIH HHS; R01 EY013124-09S1/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Viral; 0/Viral Proteins
Comments/Corrections

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