Document Detail


Computational Models and Emergent Properties of Respiratory Neural Networks.
MedLine Citation:
PMID:  23687564     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Computational models of the neural control system for breathing in mammals provide a theoretical and computational framework bringing together experimental data obtained from different animal preparations under various experimental conditions. Many of these models were developed in parallel and iteratively with experimental studies and provided predictions guiding new experiments. This data-driven modeling approach has advanced our understanding of respiratory network architecture and neural mechanisms underlying generation of the respiratory rhythm and pattern, including their functional reorganization under different physiological conditions. Models reviewed here vary in neurobiological details and computational complexity and span multiple spatiotemporal scales of respiratory control mechanisms. Recent models describe interacting populations of respiratory neurons spatially distributed within the Bötzinger and pre-Bötzinger complexes and rostral ventrolateral medulla that contain core circuits of the respiratory central pattern generator (CPG). Network interactions within these circuits along with intrinsic rhythmogenic properties of neurons form a hierarchy of multiple rhythm generation mechanisms. The functional expression of these mechanisms is controlled by input drives from other brainstem components, including the retrotrapezoid nucleus and pons, which regulate the dynamic behavior of the core circuitry. The emerging view is that the brainstem respiratory network has rhythmogenic capabilities at multiple levels of circuit organization. This allows flexible, state-dependent expression of different neural pattern-generation mechanisms under various physiological conditions, enabling a wide repertoire of respiratory behaviors. Some models consider control of the respiratory CPG by pulmonary feedback and network reconfiguration during defensive behaviors such as cough. Future directions in modeling of the respiratory CPG are considered.
Authors:
Bruce G Lindsey; Ilya A Rybak; Jeffrey C Smith
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Comprehensive Physiology     Volume:  2     ISSN:  2040-4603     ISO Abbreviation:  Compr Physiol     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2013-5-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101574442     Medline TA:  Compr Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1619-1670     Citation Subset:  -    
Affiliation:
Department of Molecular Pharmacology and Physiology and Neuroscience Program, University of South Florida College of Medicine, Tampa, Florida.
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